STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EXD1Exonuclease 3'-5' domain containing 1. (569 aa)    
Predicted Functional Partners:
EXD2
Exonuclease 3'-5' domain containing 2.
      
 0.885
TDRD5
Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity); Belongs to the TDRD5 family.
   
  
 0.829
TDRD9
Tudor domain containing 9.
   
  
 0.828
EXD3
Exonuclease 3'-5' domain containing 3.
      
 0.810
TDRKH
Tudor and KH domain containing.
      
 0.756
FKBP6
Peptidylprolyl isomerase.
   
  
 0.742
TDRD12
Tudor domain containing 12.
   
 
 0.736
BICD2
BICD cargo adaptor 2.
    
 
 0.728
BICD1
BICD cargo adaptor 1.
   
 
 0.728
HENMT1
HEN methyltransferase 1.
      
 0.723
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.