STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC5A3Sodium/myo-inositol cotransporter; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (718 aa)    
Predicted Functional Partners:
SLC6A12
Sodium- and chloride-dependent betaine transporter; Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
   
  
 0.582
NFAT5
Nuclear factor of activated T cells 5.
   
  
 0.523
LOC100856647
PKS_ER domain-containing protein.
      
 0.519
CRYZL1
PKS_ER domain-containing protein.
      
 0.519
CAPN7
Calpain 7; Belongs to the peptidase C2 family.
      
 0.518
GPLD1
Glycosylphosphatidylinositol specific phospholipase D1.
      
 0.489
KPNA3
Importin subunit alpha; Functions in nuclear protein import.
    
   0.488
SLC7A14
Solute carrier family 7 member 14.
      
 0.469
TMEM184B
Transmembrane protein 184B.
      
 0.450
AKR1B1
Uncharacterized protein.
   
  
 0.439
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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