STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PNPLA2Patatin like phospholipase domain containing 2. (459 aa)    
Predicted Functional Partners:
ABHD5
Abhydrolase domain containing 5.
    
 0.995
LPL
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
     
 0.933
MGLL
Monoglyceride lipase.
     
 0.933
AGK
Acylglycerol kinase.
   
 
 0.922
DGAT1
Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.
     
 0.921
LIPC
PLAT domain-containing protein.
     
 0.914
PLPP2
Phospholipid phosphatase 2.
   
 
 0.905
LIPF
Gastric triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.
    
 0.902
DGAT2
Diacylglycerol O-acyltransferase 2.
     
 0.893
DGKA
Diacylglycerol kinase.
     
 0.893
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.