IFIT2 protein (Canis lupus familiaris) - STRING interaction network

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IFIT2

Interferon induced protein with tetratricopeptide repeats 2. (480 aa)

Predicted Functional Partners:

RSAD2

0.859

ISG15

0.853

MX1

0.808

OASL

0.764

EIF2AK2

0.760

USP18

0.734

CXCL10

0.702

DDX58

0.696

IFI6

0.689

OAS2

0.677

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXCL10	DDX58	ENSCAFP00000032015	ENSCAFP00000002634	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	DExD/H-box helicase 58.	0.649
CXCL10	EIF2AK2	ENSCAFP00000032015	ENSCAFP00000009092	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	Eukaryotic translation initiation factor 2-alpha kinase 2.	0.475
CXCL10	IFI6	ENSCAFP00000032015	ENSCAFP00000051805	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	Interferon alpha inducible protein 6.	0.436
CXCL10	IFIT2	ENSCAFP00000032015	ENSCAFP00000014139	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	Interferon induced protein with tetratricopeptide repeats 2.	0.702
CXCL10	ISG15	ENSCAFP00000032015	ENSCAFP00000028581	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	ISG15 ubiquitin like modifier.	0.949
CXCL10	MX1	ENSCAFP00000032015	ENSCAFP00000051654	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV).	0.779
CXCL10	OAS2	ENSCAFP00000032015	ENSCAFP00000013137	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	2'-5'-oligoadenylate synthetase 2.	0.478
CXCL10	OASL	ENSCAFP00000032015	ENSCAFP00000015461	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	2'-5' oligoadenylate synthetase-like 1.	0.584
CXCL10	RSAD2	ENSCAFP00000032015	ENSCAFP00000004884	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	Radical S-adenosyl methionine domain containing 2.	0.700
CXCL10	USP18	ENSCAFP00000032015	ENSCAFP00000059634	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.701
DDX58	CXCL10	ENSCAFP00000002634	ENSCAFP00000032015	DExD/H-box helicase 58.	C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...]	0.649
DDX58	EIF2AK2	ENSCAFP00000002634	ENSCAFP00000009092	DExD/H-box helicase 58.	Eukaryotic translation initiation factor 2-alpha kinase 2.	0.952
DDX58	IFI6	ENSCAFP00000002634	ENSCAFP00000051805	DExD/H-box helicase 58.	Interferon alpha inducible protein 6.	0.516
DDX58	IFIT2	ENSCAFP00000002634	ENSCAFP00000014139	DExD/H-box helicase 58.	Interferon induced protein with tetratricopeptide repeats 2.	0.696
DDX58	ISG15	ENSCAFP00000002634	ENSCAFP00000028581	DExD/H-box helicase 58.	ISG15 ubiquitin like modifier.	0.991
DDX58	MX1	ENSCAFP00000002634	ENSCAFP00000051654	DExD/H-box helicase 58.	Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV).	0.847
DDX58	OAS2	ENSCAFP00000002634	ENSCAFP00000013137	DExD/H-box helicase 58.	2'-5'-oligoadenylate synthetase 2.	0.739
DDX58	OASL	ENSCAFP00000002634	ENSCAFP00000015461	DExD/H-box helicase 58.	2'-5' oligoadenylate synthetase-like 1.	0.830
DDX58	RSAD2	ENSCAFP00000002634	ENSCAFP00000004884	DExD/H-box helicase 58.	Radical S-adenosyl methionine domain containing 2.	0.943
DDX58	USP18	ENSCAFP00000002634	ENSCAFP00000059634	DExD/H-box helicase 58.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.925