STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SYS1Protein SYS1 homolog; Involved in protein trafficking. Belongs to the SYS1 family. (156 aa)    
Predicted Functional Partners:
ARFRP1
ADP ribosylation factor related protein 1; Belongs to the small GTPase superfamily. Arf family.
   
 
 0.911
TP53TG5
TP53 target 5.
      
 0.901
DTNBP1
Dystrobrevin binding protein 1.
      
 0.790
VPS52
Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...]
     
 0.747
RAB6A
RAB6A, member RAS oncogene family.
     
 0.729
RAB6B
RAB6B, member RAS oncogene family.
     
 0.729
PDZK1IP1
PDZK1 interacting protein 1.
      
 0.709
RIC1
RIC1 homolog, RAB6A GEF complex partner 1.
     
 0.689
SPINT3
Early lactation protein.
   
  
 0.683
AEBP1
AE binding protein 1.
    
 
 0.648
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.