STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
WFDC2WAP four-disulfide core domain protein 2; Broad range protease inhibitor (By similarity). Possible function in sperm maturation. (110 aa)    
Predicted Functional Partners:
CD52
CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
      
 0.889
NPC2-2
NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...]
      
 0.889
STRIP1
Striatin interacting protein 1.
      
 0.707
WFDC10A
WAP four-disulfide core domain 10A.
      
 0.611
MUC19
Uncharacterized protein.
   
  
 0.608
J9NTY3_CANLF
WAP domain-containing protein.
      
 0.607
LY6G5C
Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation.
      
 0.595
BACE2
Beta-secretase 2; Belongs to the peptidase A1 family.
   
 
 0.588
AGR2
Anterior gradient 2, protein disulphide isomerase family member.
   
 
 0.564
ENSCAFP00000062374
IF rod domain-containing protein; Belongs to the intermediate filament family.
   
 
 0.554
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.