STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IRAK4Interleukin 1 receptor associated kinase 4. (466 aa)    
Predicted Functional Partners:
MYD88
MYD88 innate immune signal transduction adaptor.
   
 0.999
IRAK1
Interleukin 1 receptor associated kinase 1.
  
 
0.999
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.998
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
   
 0.995
TIRAP
TIR domain containing adaptor protein.
   
 0.994
IRAK2
Interleukin 1 receptor associated kinase 2.
  
 
0.993
PELI1
E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
    
 0.986
IRAK3
Interleukin 1 receptor associated kinase 3.
  
 
0.970
IL1R1
Interleukin 1 receptor type 1.
    
 0.968
TAB2
TGF-beta activated kinase 1 (MAP3K7) binding protein 2.
    
 0.963
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.