STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TWNKTwinkle mtDNA helicase. (684 aa)    
Predicted Functional Partners:
POLG
DNA polymerase gamma, catalytic subunit.
   
 
 0.886
POLG2
DNA polymerase gamma 2, accessory subunit.
     
 0.833
NUBPL
Nucleotide binding protein like.
    
 
 0.815
CPOX
Coproporphyrinogen oxidase.
    
   0.787
TFAM
Transcription factor A, mitochondrial.
     
 0.763
PTGES2
Prostaglandin E synthase 2.
    
   0.741
POLRMT
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.
   
  
 0.739
SSBP1
Single stranded DNA binding protein 1.
   
 
 0.703
RMND1
Required for meiotic nuclear division 1 homolog.
      
 0.685
ARMC8
Armadillo repeat containing 8.
    
   0.640
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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