TWNK protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TWNK

Twinkle mtDNA helicase. (684 aa)

Predicted Functional Partners:

MRPS12

0.673

ERAL1

0.667

PUSL1

0.644

RBFA

0.625

POLRMT

0.589

GTPBP10

0.584

MTERF4

0.580

MRM3

0.572

NSUN4

0.571

MALSU1

0.566

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERAL1	GTPBP10	ENSCAFP00000027759	ENSCAFP00000002763	Era like 12S mitochondrial rRNA chaperone 1.	GTP binding protein 10.	0.588
ERAL1	MALSU1	ENSCAFP00000027759	ENSCAFP00000004063	Era like 12S mitochondrial rRNA chaperone 1.	Mitochondrial assembly of ribosomal large subunit 1.	0.525
ERAL1	MRM3	ENSCAFP00000027759	ENSCAFP00000028210	Era like 12S mitochondrial rRNA chaperone 1.	Mitochondrial rRNA methyltransferase 3.	0.561
ERAL1	MRPS12	ENSCAFP00000027759	ENSCAFP00000008389	Era like 12S mitochondrial rRNA chaperone 1.	Mitochondrial ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family.	0.938
ERAL1	MTERF4	ENSCAFP00000027759	ENSCAFP00000043998	Era like 12S mitochondrial rRNA chaperone 1.	Uncharacterized protein.	0.536
ERAL1	NSUN4	ENSCAFP00000027759	ENSCAFP00000006325	Era like 12S mitochondrial rRNA chaperone 1.	NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.597
ERAL1	POLRMT	ENSCAFP00000027759	ENSCAFP00000065440	Era like 12S mitochondrial rRNA chaperone 1.	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.	0.503
ERAL1	PUSL1	ENSCAFP00000027759	ENSCAFP00000050872	Era like 12S mitochondrial rRNA chaperone 1.	Pseudouridine synthase like 1.	0.582
ERAL1	RBFA	ENSCAFP00000027759	ENSCAFP00000032945	Era like 12S mitochondrial rRNA chaperone 1.	Uncharacterized protein.	0.635
ERAL1	TWNK	ENSCAFP00000027759	ENSCAFP00000014333	Era like 12S mitochondrial rRNA chaperone 1.	Twinkle mtDNA helicase.	0.667
GTPBP10	ERAL1	ENSCAFP00000002763	ENSCAFP00000027759	GTP binding protein 10.	Era like 12S mitochondrial rRNA chaperone 1.	0.588
GTPBP10	MALSU1	ENSCAFP00000002763	ENSCAFP00000004063	GTP binding protein 10.	Mitochondrial assembly of ribosomal large subunit 1.	0.868
GTPBP10	MRM3	ENSCAFP00000002763	ENSCAFP00000028210	GTP binding protein 10.	Mitochondrial rRNA methyltransferase 3.	0.801
GTPBP10	MTERF4	ENSCAFP00000002763	ENSCAFP00000043998	GTP binding protein 10.	Uncharacterized protein.	0.568
GTPBP10	NSUN4	ENSCAFP00000002763	ENSCAFP00000006325	GTP binding protein 10.	NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.653
GTPBP10	POLRMT	ENSCAFP00000002763	ENSCAFP00000065440	GTP binding protein 10.	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.	0.515
GTPBP10	PUSL1	ENSCAFP00000002763	ENSCAFP00000050872	GTP binding protein 10.	Pseudouridine synthase like 1.	0.632
GTPBP10	RBFA	ENSCAFP00000002763	ENSCAFP00000032945	GTP binding protein 10.	Uncharacterized protein.	0.590
GTPBP10	TWNK	ENSCAFP00000002763	ENSCAFP00000014333	GTP binding protein 10.	Twinkle mtDNA helicase.	0.584
MALSU1	ERAL1	ENSCAFP00000004063	ENSCAFP00000027759	Mitochondrial assembly of ribosomal large subunit 1.	Era like 12S mitochondrial rRNA chaperone 1.	0.525