PRICKLE1 protein (Canis lupus familiaris) - STRING interaction network

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Score

PRICKLE1

Prickle planar cell polarity protein 1. (834 aa)

Predicted Functional Partners:

VANGL1

0.993

DVL2

0.987

DVL1

0.957

DVL3

0.938

CELSR1

0.866

PSMD6

0.840

PRICKLE4

0.812

FZD6

0.795

PRICKLE3

0.795

FZD3

0.705

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CELSR1	DVL1	ENSCAFP00000040779	ENSCAFP00000028442	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 1.	0.610
CELSR1	DVL2	ENSCAFP00000040779	ENSCAFP00000023701	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 2.	0.791
CELSR1	DVL3	ENSCAFP00000040779	ENSCAFP00000017997	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Dishevelled segment polarity protein 3.	0.623
CELSR1	FZD3	ENSCAFP00000040779	ENSCAFP00000012176	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.744
CELSR1	FZD6	ENSCAFP00000040779	ENSCAFP00000000924	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	0.922
CELSR1	PRICKLE1	ENSCAFP00000040779	ENSCAFP00000014368	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 1.	0.866
CELSR1	PRICKLE3	ENSCAFP00000040779	ENSCAFP00000023232	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 3.	0.802
CELSR1	PRICKLE4	ENSCAFP00000040779	ENSCAFP00000002336	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.589
CELSR1	PSMD6	ENSCAFP00000040779	ENSCAFP00000050046	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Prickle planar cell polarity protein 2.	0.780
CELSR1	VANGL1	ENSCAFP00000040779	ENSCAFP00000030553	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	Vang-like protein.	0.931
DVL1	CELSR1	ENSCAFP00000028442	ENSCAFP00000040779	Dishevelled segment polarity protein 1.	Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family.	0.610
DVL1	DVL2	ENSCAFP00000028442	ENSCAFP00000023701	Dishevelled segment polarity protein 1.	Dishevelled segment polarity protein 2.	0.993
DVL1	DVL3	ENSCAFP00000028442	ENSCAFP00000017997	Dishevelled segment polarity protein 1.	Dishevelled segment polarity protein 3.	0.974
DVL1	FZD3	ENSCAFP00000028442	ENSCAFP00000012176	Dishevelled segment polarity protein 1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.975
DVL1	FZD6	ENSCAFP00000028442	ENSCAFP00000000924	Dishevelled segment polarity protein 1.	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	0.973
DVL1	PRICKLE1	ENSCAFP00000028442	ENSCAFP00000014368	Dishevelled segment polarity protein 1.	Prickle planar cell polarity protein 1.	0.957
DVL1	PRICKLE3	ENSCAFP00000028442	ENSCAFP00000023232	Dishevelled segment polarity protein 1.	Prickle planar cell polarity protein 3.	0.962
DVL1	PRICKLE4	ENSCAFP00000028442	ENSCAFP00000002336	Dishevelled segment polarity protein 1.	Uncharacterized protein.	0.961
DVL1	PSMD6	ENSCAFP00000028442	ENSCAFP00000050046	Dishevelled segment polarity protein 1.	Prickle planar cell polarity protein 2.	0.966
DVL1	VANGL1	ENSCAFP00000028442	ENSCAFP00000030553	Dishevelled segment polarity protein 1.	Vang-like protein.	0.985