STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HERC6HECT and RLD domain containing E3 ubiquitin protein ligase family member 6. (1012 aa)    
Predicted Functional Partners:
RNF213
Ring finger protein 213.
   
 
 0.848
RIMS4
Regulating synaptic membrane exocytosis 4.
      
 0.694
ISG15
ISG15 ubiquitin like modifier.
   
 
 0.687
PCYOX1
Prenylcysteine oxidase 1.
      
 0.679
USP18
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
   
 
 0.659
RSAD2
Radical S-adenosyl methionine domain containing 2.
   
 
 0.643
NEURL3
Neuralized E3 ubiquitin protein ligase 3.
    
 
 0.641
PSMB10
Proteasome subunit beta.
   
 
 0.630
PIGY
PIGY upstream reading frame.
   
  
 0.616
ENSCAFP00000064917
Uncharacterized protein.
      
 0.616
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.