NOD2 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

NOD2

Uncharacterized protein. (1013 aa)

Predicted Functional Partners:

RIPK2

0.998

ATG16L1

0.996

ERBIN

0.935

ATG5

0.929

TLR2

0.925

ATG12

0.909

CASP4

0.898

XIAP

0.889

MAVS

0.883

SUGT1

0.882

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG16L1	ENSCAFP00000000294	ENSCAFP00000052433	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 16 like 1.	0.999
ATG12	ATG5	ENSCAFP00000000294	ENSCAFP00000005515	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	MAVS	ENSCAFP00000000294	ENSCAFP00000009240	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral signaling protein.	0.839
ATG12	NOD2	ENSCAFP00000000294	ENSCAFP00000014425	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Uncharacterized protein.	0.909
ATG16L1	ATG12	ENSCAFP00000052433	ENSCAFP00000000294	Autophagy related 16 like 1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG16L1	ATG5	ENSCAFP00000052433	ENSCAFP00000005515	Autophagy related 16 like 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG16L1	NOD2	ENSCAFP00000052433	ENSCAFP00000014425	Autophagy related 16 like 1.	Uncharacterized protein.	0.996
ATG16L1	RIPK2	ENSCAFP00000052433	ENSCAFP00000013170	Autophagy related 16 like 1.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.800
ATG16L1	TLR2	ENSCAFP00000052433	ENSCAFP00000012269	Autophagy related 16 like 1.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.510
ATG5	ATG12	ENSCAFP00000005515	ENSCAFP00000000294	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	ATG16L1	ENSCAFP00000005515	ENSCAFP00000052433	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy related 16 like 1.	0.999
ATG5	CASP4	ENSCAFP00000005515	ENSCAFP00000031566	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.490
ATG5	MAVS	ENSCAFP00000005515	ENSCAFP00000009240	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral signaling protein.	0.870
ATG5	NOD2	ENSCAFP00000005515	ENSCAFP00000014425	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.929
CASP4	ATG5	ENSCAFP00000031566	ENSCAFP00000005515	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Autophagy protein 5; Involved in autophagic vesicle formation.	0.490
CASP4	MAVS	ENSCAFP00000031566	ENSCAFP00000009240	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Mitochondrial antiviral signaling protein.	0.497
CASP4	NOD2	ENSCAFP00000031566	ENSCAFP00000014425	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Uncharacterized protein.	0.898
CASP4	RIPK2	ENSCAFP00000031566	ENSCAFP00000013170	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.555
CASP4	TLR2	ENSCAFP00000031566	ENSCAFP00000012269	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.846
CASP4	XIAP	ENSCAFP00000031566	ENSCAFP00000034255	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Baculoviral IAP-repeat containing protein 4.	0.565