TLR9 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TLR9

Twinfilin actin binding protein 2. (349 aa)

Predicted Functional Partners:

CAPZB

0.877

TLR9-2

0.846

CELF3

0.811

CAP2

0.758

TMOD2

0.681

F1Q1C8_CANLF

0.660

CFL2

0.652

PFN4

0.639

CFL1

0.630

MTPN

0.625

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAP2	CAPZB	ENSCAFP00000014712	ENSCAFP00000065479	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.567
CAP2	CFL1	ENSCAFP00000014712	ENSCAFP00000066287	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Cofilin 1; Belongs to the actin-binding proteins ADF family.	0.688
CAP2	CFL2	ENSCAFP00000014712	ENSCAFP00000066617	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Cofilin 2; Belongs to the actin-binding proteins ADF family.	0.468
CAP2	F1Q1C8_CANLF	ENSCAFP00000014712	ENSCAFP00000016692	Adenylyl cyclase-associated protein; Belongs to the CAP family.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.688
CAP2	PFN4	ENSCAFP00000014712	ENSCAFP00000040704	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Profilin; Belongs to the profilin family.	0.592
CAP2	TLR9	ENSCAFP00000014712	ENSCAFP00000014482	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Twinfilin actin binding protein 2.	0.758
CAPZB	CAP2	ENSCAFP00000065479	ENSCAFP00000014712	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.567
CAPZB	CFL1	ENSCAFP00000065479	ENSCAFP00000066287	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Cofilin 1; Belongs to the actin-binding proteins ADF family.	0.642
CAPZB	CFL2	ENSCAFP00000065479	ENSCAFP00000066617	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Cofilin 2; Belongs to the actin-binding proteins ADF family.	0.549
CAPZB	F1Q1C8_CANLF	ENSCAFP00000065479	ENSCAFP00000016692	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.590
CAPZB	MTPN	ENSCAFP00000065479	ENSCAFP00000039244	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).	0.744
CAPZB	PFN4	ENSCAFP00000065479	ENSCAFP00000040704	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Profilin; Belongs to the profilin family.	0.656
CAPZB	TLR9	ENSCAFP00000065479	ENSCAFP00000014482	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Twinfilin actin binding protein 2.	0.877
CAPZB	TMOD2	ENSCAFP00000065479	ENSCAFP00000062539	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Tropomodulin 2.	0.450
CELF3	TLR9	ENSCAFP00000018851	ENSCAFP00000014482	CUGBP Elav-like family member 3.	Twinfilin actin binding protein 2.	0.811
CFL1	CAP2	ENSCAFP00000066287	ENSCAFP00000014712	Cofilin 1; Belongs to the actin-binding proteins ADF family.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.688
CFL1	CAPZB	ENSCAFP00000066287	ENSCAFP00000065479	Cofilin 1; Belongs to the actin-binding proteins ADF family.	Capping actin protein of muscle Z-line subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.642
CFL1	CFL2	ENSCAFP00000066287	ENSCAFP00000066617	Cofilin 1; Belongs to the actin-binding proteins ADF family.	Cofilin 2; Belongs to the actin-binding proteins ADF family.	0.933
CFL1	PFN4	ENSCAFP00000066287	ENSCAFP00000040704	Cofilin 1; Belongs to the actin-binding proteins ADF family.	Profilin; Belongs to the profilin family.	0.773
CFL1	TLR9	ENSCAFP00000066287	ENSCAFP00000014482	Cofilin 1; Belongs to the actin-binding proteins ADF family.	Twinfilin actin binding protein 2.	0.630