STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KSR2Kinase suppressor of ras 2. (950 aa)    
Predicted Functional Partners:
BRAP
BRCA1 associated protein.
    
 0.952
KSR1
Kinase suppressor of ras 1.
     
 
0.925
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
    
0.891
ARAF
A-Raf proto-oncogene, serine/threonine kinase.
    
0.891
MAP2K2
Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).
   
 0.876
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
0.872
CNKSR2
Connector enhancer of kinase suppressor of Ras 2.
    
 0.813
TMEM169
Transmembrane protein 169.
      
 0.811
CNKSR1
Connector enhancer of kinase suppressor of Ras 1.
    
 0.799
LSP1
Lymphocyte specific protein 1.
    
 0.778
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.