BTRC protein (Canis lupus familiaris) - STRING interaction network

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BTRC

Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)

Predicted Functional Partners:

FBXW11

0.999

CUL1

0.996

CTNNB1

0.995

FBXO5

0.995

RBX1

0.989

NFKBIA

0.985

GLI3

0.979

GLI1

0.978

WWTR1

0.970

YAP1

0.970

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	CTNNB1	ENSCAFP00000014526	ENSCAFP00000007783	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.995
BTRC	CUL1	ENSCAFP00000014526	ENSCAFP00000005151	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin 1; Belongs to the cullin family.	0.996
BTRC	FBXO5	ENSCAFP00000014526	ENSCAFP00000038421	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 5.	0.995
BTRC	FBXW11	ENSCAFP00000014526	ENSCAFP00000043770	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 11.	0.999
BTRC	GLI1	ENSCAFP00000014526	ENSCAFP00000061355	Beta-transducin repeat containing E3 ubiquitin protein ligase.	GLI family zinc finger 1.	0.978
BTRC	GLI3	ENSCAFP00000014526	ENSCAFP00000005264	Beta-transducin repeat containing E3 ubiquitin protein ligase.	GLI family zinc finger 3.	0.979
BTRC	NFKBIA	ENSCAFP00000014526	ENSCAFP00000019772	Beta-transducin repeat containing E3 ubiquitin protein ligase.	NFKB inhibitor alpha.	0.985
BTRC	RBX1	ENSCAFP00000014526	ENSCAFP00000051832	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Ring-box 1.	0.989
BTRC	WWTR1	ENSCAFP00000014526	ENSCAFP00000012278	Beta-transducin repeat containing E3 ubiquitin protein ligase.	WW domain containing transcription regulator 1.	0.970
BTRC	YAP1	ENSCAFP00000014526	ENSCAFP00000038782	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Yes associated protein 1.	0.970
CTNNB1	BTRC	ENSCAFP00000007783	ENSCAFP00000014526	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.995
CTNNB1	CUL1	ENSCAFP00000007783	ENSCAFP00000005151	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Cullin 1; Belongs to the cullin family.	0.674
CTNNB1	FBXW11	ENSCAFP00000007783	ENSCAFP00000043770	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	F-box and WD repeat domain containing 11.	0.993
CTNNB1	GLI1	ENSCAFP00000007783	ENSCAFP00000061355	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	GLI family zinc finger 1.	0.650
CTNNB1	GLI3	ENSCAFP00000007783	ENSCAFP00000005264	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	GLI family zinc finger 3.	0.477
CTNNB1	NFKBIA	ENSCAFP00000007783	ENSCAFP00000019772	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	NFKB inhibitor alpha.	0.418
CTNNB1	WWTR1	ENSCAFP00000007783	ENSCAFP00000012278	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	WW domain containing transcription regulator 1.	0.810
CTNNB1	YAP1	ENSCAFP00000007783	ENSCAFP00000038782	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Yes associated protein 1.	0.860
CUL1	BTRC	ENSCAFP00000005151	ENSCAFP00000014526	Cullin 1; Belongs to the cullin family.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.996
CUL1	CTNNB1	ENSCAFP00000005151	ENSCAFP00000007783	Cullin 1; Belongs to the cullin family.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.674