BTRC protein (Canis lupus familiaris) - STRING interaction network

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Score

BTRC

Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)

Predicted Functional Partners:

CUL1

0.997

CTNNB1

0.997

RBX1

0.991

SKP1

0.974

FBXW11

0.969

NFKBIA

0.964

WWTR1

0.955

YAP1

0.955

SKP2

0.947

FBXO5

0.947

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	CTNNB1	ENSCAFP00000014526	ENSCAFP00000007783	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.997
BTRC	CUL1	ENSCAFP00000014526	ENSCAFP00000005151	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin 1; Belongs to the cullin family.	0.997
BTRC	FBXO5	ENSCAFP00000014526	ENSCAFP00000038421	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 5.	0.947
BTRC	FBXW11	ENSCAFP00000014526	ENSCAFP00000043770	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 11.	0.969
BTRC	NFKBIA	ENSCAFP00000014526	ENSCAFP00000019772	Beta-transducin repeat containing E3 ubiquitin protein ligase.	NFKB inhibitor alpha.	0.964
BTRC	RBX1	ENSCAFP00000014526	ENSCAFP00000051832	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Ring-box 1.	0.991
BTRC	SKP1	ENSCAFP00000014526	ENSCAFP00000001412	Beta-transducin repeat containing E3 ubiquitin protein ligase.	S-phase kinase associated protein 1; Belongs to the SKP1 family.	0.974
BTRC	SKP2	ENSCAFP00000014526	ENSCAFP00000027621	Beta-transducin repeat containing E3 ubiquitin protein ligase.	S-phase kinase associated protein 2.	0.947
BTRC	WWTR1	ENSCAFP00000014526	ENSCAFP00000012278	Beta-transducin repeat containing E3 ubiquitin protein ligase.	WW domain containing transcription regulator 1.	0.955
BTRC	YAP1	ENSCAFP00000014526	ENSCAFP00000038782	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Yes associated protein 1.	0.955
CTNNB1	BTRC	ENSCAFP00000007783	ENSCAFP00000014526	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.997
CTNNB1	CUL1	ENSCAFP00000007783	ENSCAFP00000005151	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Cullin 1; Belongs to the cullin family.	0.500
CTNNB1	FBXW11	ENSCAFP00000007783	ENSCAFP00000043770	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	F-box and WD repeat domain containing 11.	0.977
CTNNB1	SKP1	ENSCAFP00000007783	ENSCAFP00000001412	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	S-phase kinase associated protein 1; Belongs to the SKP1 family.	0.798
CTNNB1	SKP2	ENSCAFP00000007783	ENSCAFP00000027621	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	S-phase kinase associated protein 2.	0.410
CTNNB1	WWTR1	ENSCAFP00000007783	ENSCAFP00000012278	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	WW domain containing transcription regulator 1.	0.601
CTNNB1	YAP1	ENSCAFP00000007783	ENSCAFP00000038782	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Yes associated protein 1.	0.804
CUL1	BTRC	ENSCAFP00000005151	ENSCAFP00000014526	Cullin 1; Belongs to the cullin family.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.997
CUL1	CTNNB1	ENSCAFP00000005151	ENSCAFP00000007783	Cullin 1; Belongs to the cullin family.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.500
CUL1	FBXO5	ENSCAFP00000005151	ENSCAFP00000038421	Cullin 1; Belongs to the cullin family.	F-box protein 5.	0.954