STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4929 aa)    
Predicted Functional Partners:
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 0.894
PIAS4
Protein inhibitor of activated STAT 4.
    
 0.835
NEURL4
Uncharacterized protein.
    
 
 0.782
MAPK6
Mitogen-activated protein kinase 6.
    
 
 0.758
USP32
Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family.
   
 
 0.730
DOCK10
Dedicator of cytokinesis 10; Belongs to the DOCK family.
    
   0.719
UBR4
Ubiquitin protein ligase E3 component n-recognin 4.
   
 
 0.703
HUWE1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
   
 
0.699
PGGT1B
Tripartite motif containing 36.
      
 0.693
RMND5A
Required for meiotic nuclear division 5 homolog A.
      
 0.674
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.