OCA2 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

OCA2

OCA2 melanosomal transmembrane protein. (777 aa)

Predicted Functional Partners:

TYR

0.948

SLC24A5

0.945

AMACR

0.936

ACP1

0.852

GPR143

0.813

DCT

0.714

RAB38

0.706

GET3

0.705

KITLG

0.689

HHATL

0.685

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP1	GET3	ENSCAFP00000036704	ENSCAFP00000025347	Acid phosphatase 1.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.846
ACP1	OCA2	ENSCAFP00000036704	ENSCAFP00000014591	Acid phosphatase 1.	OCA2 melanosomal transmembrane protein.	0.852
AMACR	DCT	ENSCAFP00000059485	ENSCAFP00000007942	Solute carrier family 45 member 2.	Uncharacterized protein.	0.795
AMACR	GPR143	ENSCAFP00000059485	ENSCAFP00000045974	Solute carrier family 45 member 2.	G protein-coupled receptor 143.	0.814
AMACR	KITLG	ENSCAFP00000059485	ENSCAFP00000066357	Solute carrier family 45 member 2.	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins.	0.571
AMACR	OCA2	ENSCAFP00000059485	ENSCAFP00000014591	Solute carrier family 45 member 2.	OCA2 melanosomal transmembrane protein.	0.936
AMACR	RAB38	ENSCAFP00000059485	ENSCAFP00000006534	Solute carrier family 45 member 2.	RAB38, member RAS oncogene family.	0.604
AMACR	SLC24A5	ENSCAFP00000059485	ENSCAFP00000053425	Solute carrier family 45 member 2.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.965
AMACR	TYR	ENSCAFP00000059485	ENSCAFP00000006504	Solute carrier family 45 member 2.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.917
DCT	AMACR	ENSCAFP00000007942	ENSCAFP00000059485	Uncharacterized protein.	Solute carrier family 45 member 2.	0.795
DCT	GPR143	ENSCAFP00000007942	ENSCAFP00000045974	Uncharacterized protein.	G protein-coupled receptor 143.	0.590
DCT	KITLG	ENSCAFP00000007942	ENSCAFP00000066357	Uncharacterized protein.	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins.	0.575
DCT	OCA2	ENSCAFP00000007942	ENSCAFP00000014591	Uncharacterized protein.	OCA2 melanosomal transmembrane protein.	0.714
DCT	SLC24A5	ENSCAFP00000007942	ENSCAFP00000053425	Uncharacterized protein.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.790
DCT	TYR	ENSCAFP00000007942	ENSCAFP00000006504	Uncharacterized protein.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.908
GET3	ACP1	ENSCAFP00000025347	ENSCAFP00000036704	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Acid phosphatase 1.	0.846
GET3	OCA2	ENSCAFP00000025347	ENSCAFP00000014591	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	OCA2 melanosomal transmembrane protein.	0.705
GET3	SLC24A5	ENSCAFP00000025347	ENSCAFP00000053425	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.470
GPR143	AMACR	ENSCAFP00000045974	ENSCAFP00000059485	G protein-coupled receptor 143.	Solute carrier family 45 member 2.	0.814
GPR143	DCT	ENSCAFP00000045974	ENSCAFP00000007942	G protein-coupled receptor 143.	Uncharacterized protein.	0.590