OCA2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

OCA2

OCA2 melanosomal transmembrane protein. (777 aa)

Predicted Functional Partners:

SLC24A5

0.902

TYR

0.896

ACP1

0.889

AMACR

0.876

GET3

0.864

HHATL

0.770

DCT

0.729

RAB38

0.719

STAT1

0.703

LRMDA

0.675

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP1	GET3	ENSCAFP00000036704	ENSCAFP00000025347	Acid phosphatase 1.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.887
ACP1	OCA2	ENSCAFP00000036704	ENSCAFP00000014591	Acid phosphatase 1.	OCA2 melanosomal transmembrane protein.	0.889
AMACR	DCT	ENSCAFP00000059485	ENSCAFP00000007942	Solute carrier family 45 member 2.	Uncharacterized protein.	0.720
AMACR	LRMDA	ENSCAFP00000059485	ENSCAFP00000047586	Solute carrier family 45 member 2.	Leucine rich melanocyte differentiation associated.	0.677
AMACR	OCA2	ENSCAFP00000059485	ENSCAFP00000014591	Solute carrier family 45 member 2.	OCA2 melanosomal transmembrane protein.	0.876
AMACR	RAB38	ENSCAFP00000059485	ENSCAFP00000006534	Solute carrier family 45 member 2.	RAB38, member RAS oncogene family.	0.678
AMACR	SLC24A5	ENSCAFP00000059485	ENSCAFP00000053425	Solute carrier family 45 member 2.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.877
AMACR	TYR	ENSCAFP00000059485	ENSCAFP00000006504	Solute carrier family 45 member 2.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.877
DCT	AMACR	ENSCAFP00000007942	ENSCAFP00000059485	Uncharacterized protein.	Solute carrier family 45 member 2.	0.720
DCT	OCA2	ENSCAFP00000007942	ENSCAFP00000014591	Uncharacterized protein.	OCA2 melanosomal transmembrane protein.	0.729
DCT	SLC24A5	ENSCAFP00000007942	ENSCAFP00000053425	Uncharacterized protein.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.558
DCT	TYR	ENSCAFP00000007942	ENSCAFP00000006504	Uncharacterized protein.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.760
GET3	ACP1	ENSCAFP00000025347	ENSCAFP00000036704	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	Acid phosphatase 1.	0.887
GET3	OCA2	ENSCAFP00000025347	ENSCAFP00000014591	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	OCA2 melanosomal transmembrane protein.	0.864
HHATL	OCA2	ENSCAFP00000007992	ENSCAFP00000014591	Hedgehog acyltransferase like.	OCA2 melanosomal transmembrane protein.	0.770
LRMDA	AMACR	ENSCAFP00000047586	ENSCAFP00000059485	Leucine rich melanocyte differentiation associated.	Solute carrier family 45 member 2.	0.677
LRMDA	OCA2	ENSCAFP00000047586	ENSCAFP00000014591	Leucine rich melanocyte differentiation associated.	OCA2 melanosomal transmembrane protein.	0.675
LRMDA	TYR	ENSCAFP00000047586	ENSCAFP00000006504	Leucine rich melanocyte differentiation associated.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.543
OCA2	ACP1	ENSCAFP00000014591	ENSCAFP00000036704	OCA2 melanosomal transmembrane protein.	Acid phosphatase 1.	0.889
OCA2	AMACR	ENSCAFP00000014591	ENSCAFP00000059485	OCA2 melanosomal transmembrane protein.	Solute carrier family 45 member 2.	0.876