STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FBXW4F-box and WD repeat domain containing 4. (596 aa)    
Predicted Functional Partners:
DYNC1I1
Dynein cytoplasmic 1 intermediate chain 1.
      
 0.786
CUL1
Cullin 1; Belongs to the cullin family.
   
 0.755
SKP1
S-phase kinase associated protein 1; Belongs to the SKP1 family.
    
 0.612
POLL
DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
 
 
  
 0.575
RNF32
Ring finger protein 32.
      
 0.572
CDC123
Cell division cycle 123.
   
  
 0.570
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
      
 0.564
UBFD1
Ubiquitin family domain containing 1.
   
  
 0.563
ENSCAFP00000059052
Ubiquitin-like domain-containing protein.
      
 0.563
TXNDC9
Thioredoxin domain containing 9.
    
   0.544
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.