STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)    
Predicted Functional Partners:
KCND3
Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family.
    
 0.887
KCND2
BTB domain-containing protein; Belongs to the potassium channel family.
    
 0.840
KCNIP4
Potassium voltage-gated channel interacting protein 4.
  
  
0.808
KCND1
Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family.
    
 0.734
KCNIP1
Potassium voltage-gated channel interacting protein 1.
   
 
 0.716
GRIK1
Glutamate ionotropic receptor kainate type subunit 1.
   
 
 0.626
KCNJ5
Potassium voltage-gated channel subfamily J member 5.
   
  
 0.605
KCNH2
Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
     
 0.605
KCNJ2
Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...]
   
  
 0.601
SYNDIG1
Synapse differentiation inducing 1.
   
  
 0.598
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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