STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif 15. (920 aa)    
Predicted Functional Partners:
ANGPTL6
Angiopoietin like 6.
      
 0.574
PCDH12
Protocadherin 12.
    
 
 0.570
CADM4
Cell adhesion molecule 4.
      
 0.563
ADAM30
ADAM metallopeptidase domain 30.
    
 
0.559
MMP19
Matrix metallopeptidase 19.
    
 
 0.528
SHISAL2A
Shisa like 2A.
      
 0.515
CNNM1
Cyclin and CBS domain divalent metal cation transport mediator 1.
      
 0.510
MMP17
Matrix metallopeptidase 17.
    
 
 0.494
AACS
Transmembrane protein 132B.
      
 0.494
SST
Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.
   
  
 0.483
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.