STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMCC2Transmembrane and coiled-coil domain family 2. (723 aa)    
Predicted Functional Partners:
DSTYK
Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
      
 0.877
NFASC
Neurofascin.
   
  
 0.684
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
      
 0.676
NAT9
N-acetyltransferase 9 (putative).
      
 0.672
MCEE
Methylmalonyl-CoA epimerase.
      
 0.671
TARS3
Threonyl-tRNA synthetase like 2.
      
 0.645
TM4SF5
Transmembrane 4 L six family member 5.
      
 0.639
TM2D3
TM2 domain containing 3.
      
 0.569
ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2.
      
 0.566
RDH13
Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.563
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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