STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NUAK2NUAK family kinase 2. (668 aa)    
Predicted Functional Partners:
ARHGEF17
Rho guanine nucleotide exchange factor 17.
      
 0.811
DOCK5
Dedicator of cytokinesis 5; Belongs to the DOCK family.
    
 
 0.802
PTPN14
Protein tyrosine phosphatase non-receptor type 14.
   
  
 0.791
AMOTL2
Angiomotin like 2.
   
  
 0.721
BYSL
Bystin like.
   
  
 0.678
SAV1
Salvador family WW domain containing protein 1.
      
 0.655
MED20
Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
   
  
 0.649
CRIM1
Cysteine rich transmembrane BMP regulator 1.
   
  
 0.649
ARHGAP28
Rho GTPase activating protein 28.
   
  
 0.583
PPP1R12C
Protein phosphatase 1 regulatory subunit.
    
 
 0.552
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.