STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ASCL2Achaete-scute family bHLH transcription factor 2. (194 aa)    
Predicted Functional Partners:
LGR5
Leucine rich repeat containing G protein-coupled receptor 5.
      
 0.899
OLFM4
Olfactomedin 4.
   
  
 0.886
LRIG1
Leucine rich repeats and immunoglobulin like domains 1.
   
  
 0.839
TCF4
Transcription factor 4; Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3') (By similarity). Binds to the thyroglobulin promoter.
   
 
 0.699
VIL1
Villin 1.
   
  
 0.656
EPHB2
EPH receptor B2.
   
 
 0.641
TCF12
Transcription factor 12.
   
 
 0.628
TCF3
Transcription factor 3.
   
 
 0.602
BMI1
RING-type domain-containing protein.
    
 
 0.601
HOPX
HOP homeobox.
    
 
 0.598
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.