STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ASCL2Achaete-scute family bHLH transcription factor 2. (194 aa)    
Predicted Functional Partners:
OLFM4
Olfactomedin 4.
   
  
 0.878
LGR5
Leucine rich repeat containing G protein-coupled receptor 5.
      
 0.878
LRIG1
Leucine rich repeats and immunoglobulin like domains 1.
   
  
 0.817
TCF3
Transcription factor 3.
   
 0.752
TCF4
Transcription factor 4; Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3') (By similarity). Binds to the thyroglobulin promoter.
   
 0.716
HES4
Hes family bHLH transcription factor 4.
   
 
 0.708
AXIN2
Axin 2.
      
 0.649
TCF12
Transcription factor 12.
   
 0.642
MSI1
Musashi RNA binding protein 1.
   
 
 0.617
BMI1
RING-type domain-containing protein.
    
 
 0.613
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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