RAD54L2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RAD54L2

RAD54 like 2. (1467 aa)

Predicted Functional Partners:

DYRK1A

0.870

CNOT7

0.769

RPS16

0.754

SQSTM1

0.688

DCAF7

0.678

AR

0.616

IQGAP1

0.613

IQGAP2

0.613

SLX4IP

0.607

UBXN7

0.526

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	RAD54L2	ENSCAFP00000024499	ENSCAFP00000014871	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	RAD54 like 2.	0.616
CNOT7	RAD54L2	ENSCAFP00000010257	ENSCAFP00000014871	CCR4-NOT transcription complex subunit 7.	RAD54 like 2.	0.769
DCAF7	DYRK1A	ENSCAFP00000019098	ENSCAFP00000014403	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 1A.	0.966
DCAF7	RAD54L2	ENSCAFP00000019098	ENSCAFP00000014871	DDB1 and CUL4 associated factor 7.	RAD54 like 2.	0.678
DCAF7	RPS16	ENSCAFP00000019098	ENSCAFP00000066023	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 1B.	0.962
DYRK1A	DCAF7	ENSCAFP00000014403	ENSCAFP00000019098	Dual specificity tyrosine phosphorylation regulated kinase 1A.	DDB1 and CUL4 associated factor 7.	0.966
DYRK1A	RAD54L2	ENSCAFP00000014403	ENSCAFP00000014871	Dual specificity tyrosine phosphorylation regulated kinase 1A.	RAD54 like 2.	0.870
DYRK1A	RPS16	ENSCAFP00000014403	ENSCAFP00000066023	Dual specificity tyrosine phosphorylation regulated kinase 1A.	Dual specificity tyrosine phosphorylation regulated kinase 1B.	0.875
IQGAP1	IQGAP2	ENSCAFP00000018867	ENSCAFP00000060498	IQ motif containing GTPase activating protein 1.	IQ motif containing GTPase activating protein 2.	0.881
IQGAP1	RAD54L2	ENSCAFP00000018867	ENSCAFP00000014871	IQ motif containing GTPase activating protein 1.	RAD54 like 2.	0.613
IQGAP2	IQGAP1	ENSCAFP00000060498	ENSCAFP00000018867	IQ motif containing GTPase activating protein 2.	IQ motif containing GTPase activating protein 1.	0.881
IQGAP2	RAD54L2	ENSCAFP00000060498	ENSCAFP00000014871	IQ motif containing GTPase activating protein 2.	RAD54 like 2.	0.613
RAD54L2	AR	ENSCAFP00000014871	ENSCAFP00000024499	RAD54 like 2.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.616
RAD54L2	CNOT7	ENSCAFP00000014871	ENSCAFP00000010257	RAD54 like 2.	CCR4-NOT transcription complex subunit 7.	0.769
RAD54L2	DCAF7	ENSCAFP00000014871	ENSCAFP00000019098	RAD54 like 2.	DDB1 and CUL4 associated factor 7.	0.678
RAD54L2	DYRK1A	ENSCAFP00000014871	ENSCAFP00000014403	RAD54 like 2.	Dual specificity tyrosine phosphorylation regulated kinase 1A.	0.870
RAD54L2	IQGAP1	ENSCAFP00000014871	ENSCAFP00000018867	RAD54 like 2.	IQ motif containing GTPase activating protein 1.	0.613
RAD54L2	IQGAP2	ENSCAFP00000014871	ENSCAFP00000060498	RAD54 like 2.	IQ motif containing GTPase activating protein 2.	0.613
RAD54L2	RPS16	ENSCAFP00000014871	ENSCAFP00000066023	RAD54 like 2.	Dual specificity tyrosine phosphorylation regulated kinase 1B.	0.754
RAD54L2	SLX4IP	ENSCAFP00000014871	ENSCAFP00000034630	RAD54 like 2.	SLX4 interacting protein.	0.607