APLP2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

APLP2

Amyloid beta precursor like protein 2. (763 aa)

Predicted Functional Partners:

APP

0.971

HPX

0.944

APBB2

0.929

APBB3

0.864

BACE1

0.830

NAE1

0.822

TTR

0.818

STRN3

0.790

GLG1

0.772

SORL1

0.771

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB2	APLP2	ENSCAFP00000031402	ENSCAFP00000014894	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor like protein 2.	0.929
APBB2	APP	ENSCAFP00000031402	ENSCAFP00000012583	Amyloid beta precursor protein binding family B member 2.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.970
APBB2	BACE1	ENSCAFP00000031402	ENSCAFP00000019275	Amyloid beta precursor protein binding family B member 2.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.550
APBB2	HPX	ENSCAFP00000031402	ENSCAFP00000009615	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family B member 1.	0.879
APBB3	APLP2	ENSCAFP00000008731	ENSCAFP00000014894	Amyloid beta precursor protein binding family B member 3.	Amyloid beta precursor like protein 2.	0.864
APBB3	APP	ENSCAFP00000008731	ENSCAFP00000012583	Amyloid beta precursor protein binding family B member 3.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.950
APLP2	APBB2	ENSCAFP00000014894	ENSCAFP00000031402	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein binding family B member 2.	0.929
APLP2	APBB3	ENSCAFP00000014894	ENSCAFP00000008731	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein binding family B member 3.	0.864
APLP2	APP	ENSCAFP00000014894	ENSCAFP00000012583	Amyloid beta precursor like protein 2.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.971
APLP2	BACE1	ENSCAFP00000014894	ENSCAFP00000019275	Amyloid beta precursor like protein 2.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.830
APLP2	GLG1	ENSCAFP00000014894	ENSCAFP00000032284	Amyloid beta precursor like protein 2.	Golgi glycoprotein 1.	0.772
APLP2	HPX	ENSCAFP00000014894	ENSCAFP00000009615	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein binding family B member 1.	0.944
APLP2	NAE1	ENSCAFP00000014894	ENSCAFP00000030260	Amyloid beta precursor like protein 2.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.822
APLP2	SORL1	ENSCAFP00000014894	ENSCAFP00000017344	Amyloid beta precursor like protein 2.	Sortilin related receptor 1.	0.771
APLP2	STRN3	ENSCAFP00000014894	ENSCAFP00000018910	Amyloid beta precursor like protein 2.	Striatin 3.	0.790
APLP2	TTR	ENSCAFP00000014894	ENSCAFP00000049371	Amyloid beta precursor like protein 2.	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.	0.818
APP	APBB2	ENSCAFP00000012583	ENSCAFP00000031402	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid beta precursor protein binding family B member 2.	0.970
APP	APBB3	ENSCAFP00000012583	ENSCAFP00000008731	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid beta precursor protein binding family B member 3.	0.950
APP	APLP2	ENSCAFP00000012583	ENSCAFP00000014894	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid beta precursor like protein 2.	0.971
APP	BACE1	ENSCAFP00000012583	ENSCAFP00000019275	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.995