node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APH1B | APLP2 | ENSCAFP00000037055 | ENSCAFP00000014894 | Aph-1 homolog B, gamma-secretase subunit. | Amyloid beta precursor like protein 2. | 0.525 |
APH1B | APP | ENSCAFP00000037055 | ENSCAFP00000012583 | Aph-1 homolog B, gamma-secretase subunit. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.711 |
APH1B | BACE2 | ENSCAFP00000037055 | ENSCAFP00000014920 | Aph-1 homolog B, gamma-secretase subunit. | Beta-secretase 2; Belongs to the peptidase A1 family. | 0.692 |
APH1B | PSEN2 | ENSCAFP00000037055 | ENSCAFP00000060221 | Aph-1 homolog B, gamma-secretase subunit. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.992 |
APLP1 | APLP2 | ENSCAFP00000066098 | ENSCAFP00000014894 | Amyloid beta precursor like protein 1. | Amyloid beta precursor like protein 2. | 0.411 |
APLP1 | APP | ENSCAFP00000066098 | ENSCAFP00000012583 | Amyloid beta precursor like protein 1. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.418 |
APLP1 | BACE2 | ENSCAFP00000066098 | ENSCAFP00000014920 | Amyloid beta precursor like protein 1. | Beta-secretase 2; Belongs to the peptidase A1 family. | 0.653 |
APLP1 | CACHD1 | ENSCAFP00000066098 | ENSCAFP00000027485 | Amyloid beta precursor like protein 1. | Cache domain containing 1. | 0.484 |
APLP1 | PSEN2 | ENSCAFP00000066098 | ENSCAFP00000060221 | Amyloid beta precursor like protein 1. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.593 |
APLP2 | APH1B | ENSCAFP00000014894 | ENSCAFP00000037055 | Amyloid beta precursor like protein 2. | Aph-1 homolog B, gamma-secretase subunit. | 0.525 |
APLP2 | APLP1 | ENSCAFP00000014894 | ENSCAFP00000066098 | Amyloid beta precursor like protein 2. | Amyloid beta precursor like protein 1. | 0.411 |
APLP2 | APP | ENSCAFP00000014894 | ENSCAFP00000012583 | Amyloid beta precursor like protein 2. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.572 |
APLP2 | BACE2 | ENSCAFP00000014894 | ENSCAFP00000014920 | Amyloid beta precursor like protein 2. | Beta-secretase 2; Belongs to the peptidase A1 family. | 0.631 |
APLP2 | PSEN2 | ENSCAFP00000014894 | ENSCAFP00000060221 | Amyloid beta precursor like protein 2. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.725 |
APP | APH1B | ENSCAFP00000012583 | ENSCAFP00000037055 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Aph-1 homolog B, gamma-secretase subunit. | 0.711 |
APP | APLP1 | ENSCAFP00000012583 | ENSCAFP00000066098 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Amyloid beta precursor like protein 1. | 0.418 |
APP | APLP2 | ENSCAFP00000012583 | ENSCAFP00000014894 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Amyloid beta precursor like protein 2. | 0.572 |
APP | BACE2 | ENSCAFP00000012583 | ENSCAFP00000014920 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Beta-secretase 2; Belongs to the peptidase A1 family. | 0.824 |
APP | PSEN2 | ENSCAFP00000012583 | ENSCAFP00000060221 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.972 |
APP | RTN3 | ENSCAFP00000012583 | ENSCAFP00000022196 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Reticulon. | 0.431 |