| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APLP2 | APP | ENSCAFP00000014894 | ENSCAFP00000012583 | Amyloid beta precursor like protein 2. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.971 |
| APLP2 | BACE1 | ENSCAFP00000014894 | ENSCAFP00000019275 | Amyloid beta precursor like protein 2. | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | 0.830 |
| APLP2 | BACE2 | ENSCAFP00000014894 | ENSCAFP00000014920 | Amyloid beta precursor like protein 2. | Beta-secretase 2; Belongs to the peptidase A1 family. | 0.667 |
| APLP2 | NCSTN | ENSCAFP00000014894 | ENSCAFP00000065126 | Amyloid beta precursor like protein 2. | Ncstrn_small domain-containing protein. | 0.755 |
| APLP2 | PSEN1 | ENSCAFP00000014894 | ENSCAFP00000024732 | Amyloid beta precursor like protein 2. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.716 |
| APLP2 | PSEN2 | ENSCAFP00000014894 | ENSCAFP00000060221 | Amyloid beta precursor like protein 2. | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.747 |
| APP | APLP2 | ENSCAFP00000012583 | ENSCAFP00000014894 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Amyloid beta precursor like protein 2. | 0.971 |
| APP | BACE1 | ENSCAFP00000012583 | ENSCAFP00000019275 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | 0.995 |
| APP | BACE2 | ENSCAFP00000012583 | ENSCAFP00000014920 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Beta-secretase 2; Belongs to the peptidase A1 family. | 0.908 |
| APP | NCSTN | ENSCAFP00000012583 | ENSCAFP00000065126 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Ncstrn_small domain-containing protein. | 0.968 |
| APP | PSEN1 | ENSCAFP00000012583 | ENSCAFP00000024732 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.996 |
| APP | PSEN2 | ENSCAFP00000012583 | ENSCAFP00000060221 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. | 0.979 |
| APP | RTN3 | ENSCAFP00000012583 | ENSCAFP00000022196 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Reticulon. | 0.449 |
| BACE1 | APLP2 | ENSCAFP00000019275 | ENSCAFP00000014894 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | Amyloid beta precursor like protein 2. | 0.830 |
| BACE1 | APP | ENSCAFP00000019275 | ENSCAFP00000012583 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.995 |
| BACE1 | BACE2 | ENSCAFP00000019275 | ENSCAFP00000014920 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | Beta-secretase 2; Belongs to the peptidase A1 family. | 0.881 |
| BACE1 | ENSCAFP00000053718 | ENSCAFP00000019275 | ENSCAFP00000053718 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | Uncharacterized protein. | 0.847 |
| BACE1 | GGA1 | ENSCAFP00000019275 | ENSCAFP00000053910 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | Golgi associated, gamma adaptin ear containing, ARF binding protein 1. | 0.945 |
| BACE1 | NCSTN | ENSCAFP00000019275 | ENSCAFP00000065126 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | Ncstrn_small domain-containing protein. | 0.776 |
| BACE1 | PSEN1 | ENSCAFP00000019275 | ENSCAFP00000024732 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] | 0.901 |
