TPMT protein (Canis lupus familiaris) - STRING interaction network

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Score

TPMT

Thiopurine S-methyltransferase. (245 aa)

Predicted Functional Partners:

GMPS

0.934

IMPDH2

0.923

IMPDH1

0.915

XDH

0.914

ITPA

0.857

ENSCAFP00000047928

0.857

HPRT1

0.822

ENSCAFP00000063281

0.822

NUDT15

0.779

PRTFDC1

0.712

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000047928	ENSCAFP00000063281	ENSCAFP00000047928	ENSCAFP00000063281	Uncharacterized protein.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.637
ENSCAFP00000047928	GMPS	ENSCAFP00000047928	ENSCAFP00000036506	Uncharacterized protein.	Uncharacterized protein.	0.858
ENSCAFP00000047928	HPRT1	ENSCAFP00000047928	ENSCAFP00000037274	Uncharacterized protein.	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).	0.637
ENSCAFP00000047928	IMPDH1	ENSCAFP00000047928	ENSCAFP00000002420	Uncharacterized protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.825
ENSCAFP00000047928	IMPDH2	ENSCAFP00000047928	ENSCAFP00000017589	Uncharacterized protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.830
ENSCAFP00000047928	NUDT15	ENSCAFP00000047928	ENSCAFP00000006639	Uncharacterized protein.	Nudix hydrolase 15.	0.454
ENSCAFP00000047928	PRTFDC1	ENSCAFP00000047928	ENSCAFP00000006330	Uncharacterized protein.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.584
ENSCAFP00000047928	TPMT	ENSCAFP00000047928	ENSCAFP00000014924	Uncharacterized protein.	Thiopurine S-methyltransferase.	0.857
ENSCAFP00000063281	ENSCAFP00000047928	ENSCAFP00000063281	ENSCAFP00000047928	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Uncharacterized protein.	0.637
ENSCAFP00000063281	GMPS	ENSCAFP00000063281	ENSCAFP00000036506	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Uncharacterized protein.	0.859
ENSCAFP00000063281	IMPDH1	ENSCAFP00000063281	ENSCAFP00000002420	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.835
ENSCAFP00000063281	IMPDH2	ENSCAFP00000063281	ENSCAFP00000017589	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.839
ENSCAFP00000063281	ITPA	ENSCAFP00000063281	ENSCAFP00000040380	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.637
ENSCAFP00000063281	TPMT	ENSCAFP00000063281	ENSCAFP00000014924	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Thiopurine S-methyltransferase.	0.822
ENSCAFP00000063281	XDH	ENSCAFP00000063281	ENSCAFP00000035983	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Xanthine dehydrogenase.	0.792
GMPS	ENSCAFP00000047928	ENSCAFP00000036506	ENSCAFP00000047928	Uncharacterized protein.	Uncharacterized protein.	0.858
GMPS	ENSCAFP00000063281	ENSCAFP00000036506	ENSCAFP00000063281	Uncharacterized protein.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.859
GMPS	HPRT1	ENSCAFP00000036506	ENSCAFP00000037274	Uncharacterized protein.	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).	0.889
GMPS	IMPDH1	ENSCAFP00000036506	ENSCAFP00000002420	Uncharacterized protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.995
GMPS	IMPDH2	ENSCAFP00000036506	ENSCAFP00000017589	Uncharacterized protein.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.993