STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FBXL15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. (300 aa)    
Predicted Functional Partners:
CUL1
Cullin 1; Belongs to the cullin family.
   
 0.972
CRY1
Cryptochrome circadian regulator 1.
   
 0.823
CRY2
Cryptochrome circadian regulator 2.
   
 0.823
RBX1
Ring-box 1.
    
 0.822
ENSCAFP00000063226
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.811
ANKRD9
Ankyrin repeat domain 9.
    
 0.741
SPSB3
SplA/ryanodine receptor domain and SOCS box containing 3.
   
 
 0.708
SKP1
S-phase kinase associated protein 1; Belongs to the SKP1 family.
    
 0.698
ENSCAFP00000049197
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.698
ENSCAFP00000051783
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.698
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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