STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDH22Cadherin 22; Cadherins are calcium-dependent cell adhesion proteins. (825 aa)    
Predicted Functional Partners:
CDH26
Cadherin 26.
   
 
 
0.934
CTNNB1
Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]
    
 0.932
CDH9
Cadherin 9; Cadherins are calcium-dependent cell adhesion proteins.
   
 
 
0.926
JUP
Uncharacterized protein.
    
 0.923
LOC102154778
Uncharacterized protein.
   
 0.920
CTNNA1
Catenin alpha 1.
   
 0.920
CDH19
Cadherin 19; Cadherins are calcium-dependent cell adhesion proteins.
   
 
 
0.913
CDH12
Cadherin 12; Cadherins are calcium-dependent cell adhesion proteins.
  
 
0.909
CDH8
Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins.
  
 
0.907
CDH20
Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.
   
 
 
0.904
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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