BDNF protein (Canis lupus familiaris) - STRING interaction network

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BDNF

Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (323 aa)

Predicted Functional Partners:

NTRK2

0.997

NTRK1

0.971

NTRK3

0.964

NGFR

0.962

GDNF

0.948

ERBB4

0.924

SORT1

0.924

EGFR

0.916

FLT1

0.906

FGFR4

0.894

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	EGFR	ENSCAFP00000014984	ENSCAFP00000005164	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Receptor protein-tyrosine kinase.	0.916
BDNF	ERBB4	ENSCAFP00000014984	ENSCAFP00000048210	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Receptor protein-tyrosine kinase.	0.924
BDNF	FGFR4	ENSCAFP00000014984	ENSCAFP00000024307	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Fibroblast growth factor receptor.	0.894
BDNF	FLT1	ENSCAFP00000014984	ENSCAFP00000010012	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.906
BDNF	GDNF	ENSCAFP00000014984	ENSCAFP00000042228	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Glial cell derived neurotrophic factor.	0.948
BDNF	NGFR	ENSCAFP00000014984	ENSCAFP00000042847	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Nerve growth factor receptor.	0.962
BDNF	NTRK1	ENSCAFP00000014984	ENSCAFP00000052728	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase receptor.	0.971
BDNF	NTRK2	ENSCAFP00000014984	ENSCAFP00000063233	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase receptor.	0.997
BDNF	NTRK3	ENSCAFP00000014984	ENSCAFP00000043465	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase receptor.	0.964
BDNF	SORT1	ENSCAFP00000014984	ENSCAFP00000048566	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Sortilin.	0.924
EGFR	BDNF	ENSCAFP00000005164	ENSCAFP00000014984	Receptor protein-tyrosine kinase.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.916
EGFR	ERBB4	ENSCAFP00000005164	ENSCAFP00000048210	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.966
EGFR	FGFR4	ENSCAFP00000005164	ENSCAFP00000024307	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.818
EGFR	FLT1	ENSCAFP00000005164	ENSCAFP00000010012	Receptor protein-tyrosine kinase.	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.542
EGFR	GDNF	ENSCAFP00000005164	ENSCAFP00000042228	Receptor protein-tyrosine kinase.	Glial cell derived neurotrophic factor.	0.905
EGFR	NTRK1	ENSCAFP00000005164	ENSCAFP00000052728	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.759
EGFR	NTRK2	ENSCAFP00000005164	ENSCAFP00000063233	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.877
EGFR	NTRK3	ENSCAFP00000005164	ENSCAFP00000043465	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.779
ERBB4	BDNF	ENSCAFP00000048210	ENSCAFP00000014984	Receptor protein-tyrosine kinase.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.924
ERBB4	EGFR	ENSCAFP00000048210	ENSCAFP00000005164	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.966

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