Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FAM124BUncharacterized protein. (460 aa)    
Predicted Functional Partners:
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
    
 
 0.667
CHD7
Chromodomain helicase DNA binding protein 7.
    
 
 0.634
MDFI
MyoD family inhibitor.
    
   0.573
ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2.
      
 0.527
RCN2
Reticulocalbin 2.
      
 0.518
RPP38
Ribonuclease P/MRP subunit p38.
      
 0.474
CHD9
Chromodomain helicase DNA binding protein 9.
    
 
 0.449
PKP2
Plakophilin 2.
    
 
 0.417
ADAL
Adenosine deaminase like.
    
 
 0.415
CHD6
Chromodomain helicase DNA binding protein 6.
    
 
 0.408
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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