STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM124BUncharacterized protein. (460 aa)    
Predicted Functional Partners:
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
      
 0.672
RCN2
Reticulocalbin 2.
      
 0.644
CHD7
Chromodomain helicase DNA binding protein 7.
   
  
 0.588
FAM174B
Uncharacterized protein.
      
 0.577
ZBTB12
Zinc finger and BTB domain containing 12.
    
 
 0.553
LY6G6F
Ig-like domain-containing protein.
   
  
 0.524
SCAPER
S-phase cyclin A associated protein in the ER.
      
 0.523
MPV17L
Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.
   
  
 0.522
GABBR1
Gamma-aminobutyric acid type B receptor subunit 1; Belongs to the G-protein coupled receptor 3 family.
   
  
 0.501
P2RY1
Purinergic receptor P2Y1 variant 1; Belongs to the G-protein coupled receptor 1 family.
      
 0.499
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.