| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP6AP2 | CTSD | ENSCAFP00000044101 | ENSCAFP00000014791 | ATPase H+ transporting accessory protein 2. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.885 |
| ATP6AP2 | CTSE | ENSCAFP00000044101 | ENSCAFP00000014987 | ATPase H+ transporting accessory protein 2. | Cathepsin E; Belongs to the peptidase A1 family. | 0.757 |
| CMA1 | CTSA | ENSCAFP00000018316 | ENSCAFP00000014432 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.557 |
| CMA1 | CTSB | ENSCAFP00000018316 | ENSCAFP00000059573 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | Cathepsin B; Belongs to the peptidase C1 family. | 0.638 |
| CMA1 | CTSD | ENSCAFP00000018316 | ENSCAFP00000014791 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.671 |
| CMA1 | CTSE | ENSCAFP00000018316 | ENSCAFP00000014987 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | Cathepsin E; Belongs to the peptidase A1 family. | 0.797 |
| CMA1 | CTSH | ENSCAFP00000018316 | ENSCAFP00000031547 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | Cathepsin H; Belongs to the peptidase C1 family. | 0.510 |
| CMA1 | CTSO | ENSCAFP00000018316 | ENSCAFP00000012615 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | Cathepsin O; Belongs to the peptidase C1 family. | 0.497 |
| CMA1 | CTSS | ENSCAFP00000018316 | ENSCAFP00000017782 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). | 0.586 |
| CMA1 | CTSZ | ENSCAFP00000018316 | ENSCAFP00000047997 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | Cathepsin Z; Belongs to the peptidase C1 family. | 0.536 |
| CTSA | CMA1 | ENSCAFP00000014432 | ENSCAFP00000018316 | Carboxypeptidase; Belongs to the peptidase S10 family. | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | 0.557 |
| CTSA | CTSB | ENSCAFP00000014432 | ENSCAFP00000059573 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin B; Belongs to the peptidase C1 family. | 0.949 |
| CTSA | CTSD | ENSCAFP00000014432 | ENSCAFP00000014791 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.869 |
| CTSA | CTSE | ENSCAFP00000014432 | ENSCAFP00000014987 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin E; Belongs to the peptidase A1 family. | 0.764 |
| CTSA | CTSH | ENSCAFP00000014432 | ENSCAFP00000031547 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin H; Belongs to the peptidase C1 family. | 0.885 |
| CTSA | CTSK | ENSCAFP00000014432 | ENSCAFP00000017808 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. | 0.747 |
| CTSA | CTSO | ENSCAFP00000014432 | ENSCAFP00000012615 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin O; Belongs to the peptidase C1 family. | 0.808 |
| CTSA | CTSS | ENSCAFP00000014432 | ENSCAFP00000017782 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). | 0.834 |
| CTSA | CTSZ | ENSCAFP00000014432 | ENSCAFP00000047997 | Carboxypeptidase; Belongs to the peptidase S10 family. | Cathepsin Z; Belongs to the peptidase C1 family. | 0.915 |
| CTSB | CMA1 | ENSCAFP00000059573 | ENSCAFP00000018316 | Cathepsin B; Belongs to the peptidase C1 family. | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | 0.638 |