STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RIPK4Receptor interacting serine/threonine kinase 4. (743 aa)    
Predicted Functional Partners:
SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1.
    
 0.816
E2RBZ7_CANLF
Uncharacterized protein.
   
 0.804
NBR1
NBR1 autophagy cargo receptor.
   
 0.737
MIB2
Mindbomb E3 ubiquitin protein ligase 2.
   
 0.729
PRKCD
Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...]
   
 0.710
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.699
LRRC19
Leucine rich repeat containing 19.
    
 0.692
ACP5
Tartrate-resistant acid phosphatase type 5.
    
 0.673
FAS
Fas cell surface death receptor.
   
 0.665
COL8A1
Collagen type VIII alpha 1 chain.
    
 0.658
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.