node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP4B | CBLIF | ENSCAFP00000009569 | ENSCAFP00000015184 | Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family. | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | 0.833 |
ATP4B | GAST | ENSCAFP00000009569 | ENSCAFP00000023420 | Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family. | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. | 0.455 |
ATP4B | TCN1 | ENSCAFP00000009569 | ENSCAFP00000015203 | Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family. | Transcobalamin 1. | 0.576 |
ATP4B | VEGFB | ENSCAFP00000009569 | ENSCAFP00000021479 | Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family. | Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. | 0.488 |
BHLHA15 | CBLIF | ENSCAFP00000022712 | ENSCAFP00000015184 | Basic helix-loop-helix family member a15. | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | 0.709 |
BHLHA15 | TCN1 | ENSCAFP00000022712 | ENSCAFP00000015203 | Basic helix-loop-helix family member a15. | Transcobalamin 1. | 0.569 |
BHLHA15 | TFF2 | ENSCAFP00000022712 | ENSCAFP00000057618 | Basic helix-loop-helix family member a15. | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). | 0.514 |
CAPN8 | CBLIF | ENSCAFP00000024188 | ENSCAFP00000015184 | Calpain 8; Belongs to the peptidase C2 family. | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | 0.656 |
CAPN8 | TCN1 | ENSCAFP00000024188 | ENSCAFP00000015203 | Calpain 8; Belongs to the peptidase C2 family. | Transcobalamin 1. | 0.655 |
CBL | CBLIF | ENSCAFP00000046273 | ENSCAFP00000015184 | Cbl proto-oncogene. | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | 0.707 |
CBL | CUBN | ENSCAFP00000046273 | ENSCAFP00000006833 | Cbl proto-oncogene. | Cubilin; Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal t [...] | 0.633 |
CBL | TCN1 | ENSCAFP00000046273 | ENSCAFP00000015203 | Cbl proto-oncogene. | Transcobalamin 1. | 0.599 |
CBLIF | ATP4B | ENSCAFP00000015184 | ENSCAFP00000009569 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family. | 0.833 |
CBLIF | BHLHA15 | ENSCAFP00000015184 | ENSCAFP00000022712 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Basic helix-loop-helix family member a15. | 0.709 |
CBLIF | CAPN8 | ENSCAFP00000015184 | ENSCAFP00000024188 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Calpain 8; Belongs to the peptidase C2 family. | 0.656 |
CBLIF | CBL | ENSCAFP00000015184 | ENSCAFP00000046273 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Cbl proto-oncogene. | 0.707 |
CBLIF | CUBN | ENSCAFP00000015184 | ENSCAFP00000006833 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Cubilin; Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal t [...] | 0.997 |
CBLIF | GAST | ENSCAFP00000015184 | ENSCAFP00000023420 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine; Belongs to the gastrin/cholecystokinin family. | 0.671 |
CBLIF | PDILT | ENSCAFP00000015184 | ENSCAFP00000026620 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Protein disulfide isomerase like, testis expressed. | 0.571 |
CBLIF | TCN1 | ENSCAFP00000015184 | ENSCAFP00000015203 | Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). | Transcobalamin 1. | 0.928 |