STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INAInternexin neuronal intermediate filament protein alpha; Belongs to the intermediate filament family. (500 aa)    
Predicted Functional Partners:
NEFL
Neurofilament light; Belongs to the intermediate filament family.
   
 
 0.983
NEFH
Neurofilament heavy; Belongs to the intermediate filament family.
   
 
 0.871
NEFM
Neurofilament medium; Belongs to the intermediate filament family.
   
 
 0.871
GAN
Gigaxonin.
    
 
 0.856
PRPH
Peripherin; Belongs to the intermediate filament family.
   
  0.843
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
   0.838
ENSCAFP00000047935
IF rod domain-containing protein; Belongs to the intermediate filament family.
   
 
 0.734
DES
Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...]
   
 
 0.734
ENSCAFP00000062374
IF rod domain-containing protein; Belongs to the intermediate filament family.
    
 
 0.686
KLC3
Kinesin light chain 3.
    
 0.633
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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