DPP4 protein (Canis lupus familiaris) - STRING interaction network

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DPP4

Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (732 aa)

Predicted Functional Partners:

ACE2

0.989

GLP1R

0.953

MME

0.952

ADA

0.945

PRCP

0.923

ANPEP

0.913

XPNPEP2

0.906

MEP1A

0.903

GCG

0.902

MEP1B

0.902

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	ANPEP	ENSCAFP00000041771	ENSCAFP00000017681	Angiotensin-converting enzyme.	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	0.895
ACE2	DPP4	ENSCAFP00000041771	ENSCAFP00000015290	Angiotensin-converting enzyme.	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	0.989
ACE2	GCG	ENSCAFP00000041771	ENSCAFP00000015307	Angiotensin-converting enzyme.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	0.792
ACE2	MEP1A	ENSCAFP00000041771	ENSCAFP00000003016	Angiotensin-converting enzyme.	Meprin A subunit.	0.923
ACE2	MEP1B	ENSCAFP00000041771	ENSCAFP00000026614	Angiotensin-converting enzyme.	Meprin A subunit.	0.928
ACE2	MME	ENSCAFP00000041771	ENSCAFP00000064509	Angiotensin-converting enzyme.	Uncharacterized protein.	0.980
ACE2	PRCP	ENSCAFP00000041771	ENSCAFP00000006911	Angiotensin-converting enzyme.	Prolylcarboxypeptidase.	0.933
ACE2	XPNPEP2	ENSCAFP00000041771	ENSCAFP00000027593	Angiotensin-converting enzyme.	X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family.	0.904
ADA	DPP4	ENSCAFP00000063170	ENSCAFP00000015290	Adenosine deaminase.	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	0.945
ADA	GCG	ENSCAFP00000063170	ENSCAFP00000015307	Adenosine deaminase.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	0.647
ANPEP	ACE2	ENSCAFP00000017681	ENSCAFP00000041771	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Angiotensin-converting enzyme.	0.895
ANPEP	DPP4	ENSCAFP00000017681	ENSCAFP00000015290	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	0.913
ANPEP	MME	ENSCAFP00000017681	ENSCAFP00000064509	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Uncharacterized protein.	0.691
ANPEP	PRCP	ENSCAFP00000017681	ENSCAFP00000006911	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	Prolylcarboxypeptidase.	0.400
ANPEP	XPNPEP2	ENSCAFP00000017681	ENSCAFP00000027593	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family.	0.532
DPP4	ACE2	ENSCAFP00000015290	ENSCAFP00000041771	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Angiotensin-converting enzyme.	0.989
DPP4	ADA	ENSCAFP00000015290	ENSCAFP00000063170	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Adenosine deaminase.	0.945
DPP4	ANPEP	ENSCAFP00000015290	ENSCAFP00000017681	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...]	0.913
DPP4	GCG	ENSCAFP00000015290	ENSCAFP00000015307	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...]	0.902
DPP4	GLP1R	ENSCAFP00000015290	ENSCAFP00000002240	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.	0.953