IRX1 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

IRX1

Iroquois homeobox 1. (511 aa)

Predicted Functional Partners:

IRX4

0.929

IRX6

0.926

DLX1

0.775

IRX2

0.746

ADAMTS16

0.746

DLX2

0.719

CLK4

0.707

FOXP1

0.636

ANHX

0.618

HEY1

0.611

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS16	IRX1	ENSCAFP00000046525	ENSCAFP00000015312	ADAM metallopeptidase with thrombospondin type 1 motif 16.	Iroquois homeobox 1.	0.746
ANHX	CLK4	ENSCAFP00000008822	ENSCAFP00000060127	Anomalous homeobox.	CDC like kinase 4; Belongs to the protein kinase superfamily.	0.609
ANHX	DLX1	ENSCAFP00000008822	ENSCAFP00000064473	Anomalous homeobox.	Distal-less homeobox 1.	0.442
ANHX	IRX1	ENSCAFP00000008822	ENSCAFP00000015312	Anomalous homeobox.	Iroquois homeobox 1.	0.618
CLK4	ANHX	ENSCAFP00000060127	ENSCAFP00000008822	CDC like kinase 4; Belongs to the protein kinase superfamily.	Anomalous homeobox.	0.609
CLK4	HEY1	ENSCAFP00000060127	ENSCAFP00000012336	CDC like kinase 4; Belongs to the protein kinase superfamily.	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	0.517
CLK4	IRX1	ENSCAFP00000060127	ENSCAFP00000015312	CDC like kinase 4; Belongs to the protein kinase superfamily.	Iroquois homeobox 1.	0.707
DLX1	ANHX	ENSCAFP00000064473	ENSCAFP00000008822	Distal-less homeobox 1.	Anomalous homeobox.	0.442
DLX1	DLX2	ENSCAFP00000064473	ENSCAFP00000031627	Distal-less homeobox 1.	Distal-less homeobox 2.	0.884
DLX1	IRX1	ENSCAFP00000064473	ENSCAFP00000015312	Distal-less homeobox 1.	Iroquois homeobox 1.	0.775
DLX1	IRX2	ENSCAFP00000064473	ENSCAFP00000015332	Distal-less homeobox 1.	Iroquois homeobox 2.	0.486
DLX2	DLX1	ENSCAFP00000031627	ENSCAFP00000064473	Distal-less homeobox 2.	Distal-less homeobox 1.	0.884
DLX2	IRX1	ENSCAFP00000031627	ENSCAFP00000015312	Distal-less homeobox 2.	Iroquois homeobox 1.	0.719
DLX2	IRX2	ENSCAFP00000031627	ENSCAFP00000015332	Distal-less homeobox 2.	Iroquois homeobox 2.	0.497
FOXP1	IRX1	ENSCAFP00000056417	ENSCAFP00000015312	Forkhead box P1.	Iroquois homeobox 1.	0.636
HEY1	CLK4	ENSCAFP00000012336	ENSCAFP00000060127	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	CDC like kinase 4; Belongs to the protein kinase superfamily.	0.517
HEY1	IRX1	ENSCAFP00000012336	ENSCAFP00000015312	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	Iroquois homeobox 1.	0.611
HEY1	IRX4	ENSCAFP00000012336	ENSCAFP00000015338	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	Iroquois homeobox 4.	0.465
IRX1	ADAMTS16	ENSCAFP00000015312	ENSCAFP00000046525	Iroquois homeobox 1.	ADAM metallopeptidase with thrombospondin type 1 motif 16.	0.746
IRX1	ANHX	ENSCAFP00000015312	ENSCAFP00000008822	Iroquois homeobox 1.	Anomalous homeobox.	0.618