STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
ADH5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa)    
Predicted Functional Partners:
ESD
S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.
 0.933
ALDH1A1
Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.
  
 0.723
ADHFE1
Alcohol dehydrogenase iron containing 1.
    
 0.722
AOX4
Uncharacterized protein.
   
 
 0.684
ALDH1A3
Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.
  
 0.677
ALDH3A1
Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
  
 0.675
LOC479911
Glutathione S-transferase.
   
 0.671
ALDH7A1
Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family.
  
 0.669
ALDH9A1
Aldehyde dehydrogenase 9 family member A1; Belongs to the aldehyde dehydrogenase family.
  
 0.666
ALDH3A2
Multidrug and toxin extrusion protein; Belongs to the aldehyde dehydrogenase family.
  
 0.664
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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