TDP2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TDP2

Tyrosyl-DNA phosphodiesterase 2. (330 aa)

Predicted Functional Partners:

YPEL3

0.792

TDP1

0.781

ACOT13

0.774

FEN1

0.686

ZNF398

0.623

KIAA0319

0.619

EMG1

0.618

PCMT1

0.614

BAG4

0.609

POLR1A

0.609

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOT13	BAG4	ENSCAFP00000055859	ENSCAFP00000009180	Acyl-CoA thioesterase 13.	BCL2 associated athanogene 4.	0.634
ACOT13	EMG1	ENSCAFP00000055859	ENSCAFP00000021292	Acyl-CoA thioesterase 13.	EMG1 N1-specific pseudouridine methyltransferase.	0.638
ACOT13	KIAA0319	ENSCAFP00000055859	ENSCAFP00000040164	Acyl-CoA thioesterase 13.	KIAA0319.	0.434
ACOT13	PCMT1	ENSCAFP00000055859	ENSCAFP00000000571	Acyl-CoA thioesterase 13.	Protein-L-isoaspartate O-methyltransferase.	0.650
ACOT13	TDP2	ENSCAFP00000055859	ENSCAFP00000015328	Acyl-CoA thioesterase 13.	Tyrosyl-DNA phosphodiesterase 2.	0.774
ACOT13	YPEL3	ENSCAFP00000055859	ENSCAFP00000055036	Acyl-CoA thioesterase 13.	Yippee like 3.	0.798
ACOT13	ZNF398	ENSCAFP00000055859	ENSCAFP00000006613	Acyl-CoA thioesterase 13.	Zinc finger protein 398.	0.681
BAG4	ACOT13	ENSCAFP00000009180	ENSCAFP00000055859	BCL2 associated athanogene 4.	Acyl-CoA thioesterase 13.	0.634
BAG4	EMG1	ENSCAFP00000009180	ENSCAFP00000021292	BCL2 associated athanogene 4.	EMG1 N1-specific pseudouridine methyltransferase.	0.624
BAG4	PCMT1	ENSCAFP00000009180	ENSCAFP00000000571	BCL2 associated athanogene 4.	Protein-L-isoaspartate O-methyltransferase.	0.638
BAG4	TDP2	ENSCAFP00000009180	ENSCAFP00000015328	BCL2 associated athanogene 4.	Tyrosyl-DNA phosphodiesterase 2.	0.609
BAG4	YPEL3	ENSCAFP00000009180	ENSCAFP00000055036	BCL2 associated athanogene 4.	Yippee like 3.	0.796
BAG4	ZNF398	ENSCAFP00000009180	ENSCAFP00000006613	BCL2 associated athanogene 4.	Zinc finger protein 398.	0.681
EMG1	ACOT13	ENSCAFP00000021292	ENSCAFP00000055859	EMG1 N1-specific pseudouridine methyltransferase.	Acyl-CoA thioesterase 13.	0.638
EMG1	BAG4	ENSCAFP00000021292	ENSCAFP00000009180	EMG1 N1-specific pseudouridine methyltransferase.	BCL2 associated athanogene 4.	0.624
EMG1	PCMT1	ENSCAFP00000021292	ENSCAFP00000000571	EMG1 N1-specific pseudouridine methyltransferase.	Protein-L-isoaspartate O-methyltransferase.	0.615
EMG1	TDP2	ENSCAFP00000021292	ENSCAFP00000015328	EMG1 N1-specific pseudouridine methyltransferase.	Tyrosyl-DNA phosphodiesterase 2.	0.618
EMG1	YPEL3	ENSCAFP00000021292	ENSCAFP00000055036	EMG1 N1-specific pseudouridine methyltransferase.	Yippee like 3.	0.717
EMG1	ZNF398	ENSCAFP00000021292	ENSCAFP00000006613	EMG1 N1-specific pseudouridine methyltransferase.	Zinc finger protein 398.	0.673
FEN1	TDP1	ENSCAFP00000043067	ENSCAFP00000055116	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Tyrosyl-DNA phosphodiesterase 1.	0.723