IRX4 protein (Canis lupus familiaris) - STRING interaction network

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Score

IRX4

Iroquois homeobox 4. (184 aa)

Predicted Functional Partners:

IRX1

0.929

NPPA

0.732

KCNJ3

0.731

GJA5

0.694

TRARG1

0.631

CDK15

0.606

SLC2A10

0.596

HAND2

0.566

SCN5A

0.559

FOXL1

0.532

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK15	IRX4	ENSCAFP00000018253	ENSCAFP00000015338	Cyclin dependent kinase 15; Belongs to the protein kinase superfamily.	Iroquois homeobox 4.	0.606
CDK15	TRARG1	ENSCAFP00000018253	ENSCAFP00000028136	Cyclin dependent kinase 15; Belongs to the protein kinase superfamily.	Trafficking regulator of GLUT4 (SLC2A4) 1.	0.831
FOXL1	IRX4	ENSCAFP00000029496	ENSCAFP00000015338	Forkhead box L1.	Iroquois homeobox 4.	0.532
GJA5	IRX4	ENSCAFP00000016302	ENSCAFP00000015338	Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Iroquois homeobox 4.	0.694
GJA5	KCNJ3	ENSCAFP00000016302	ENSCAFP00000013508	Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Potassium voltage-gated channel subfamily J member 3.	0.475
GJA5	NPPA	ENSCAFP00000016302	ENSCAFP00000053231	Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.699
GJA5	SCN5A	ENSCAFP00000016302	ENSCAFP00000007532	Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.842
HAND2	IRX1	ENSCAFP00000011616	ENSCAFP00000015312	Heart and neural crest derivatives expressed 2.	Iroquois homeobox 1.	0.408
HAND2	IRX4	ENSCAFP00000011616	ENSCAFP00000015338	Heart and neural crest derivatives expressed 2.	Iroquois homeobox 4.	0.566
HAND2	NPPA	ENSCAFP00000011616	ENSCAFP00000053231	Heart and neural crest derivatives expressed 2.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.534
IRX1	HAND2	ENSCAFP00000015312	ENSCAFP00000011616	Iroquois homeobox 1.	Heart and neural crest derivatives expressed 2.	0.408
IRX1	IRX4	ENSCAFP00000015312	ENSCAFP00000015338	Iroquois homeobox 1.	Iroquois homeobox 4.	0.929
IRX4	CDK15	ENSCAFP00000015338	ENSCAFP00000018253	Iroquois homeobox 4.	Cyclin dependent kinase 15; Belongs to the protein kinase superfamily.	0.606
IRX4	FOXL1	ENSCAFP00000015338	ENSCAFP00000029496	Iroquois homeobox 4.	Forkhead box L1.	0.532
IRX4	GJA5	ENSCAFP00000015338	ENSCAFP00000016302	Iroquois homeobox 4.	Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.694
IRX4	HAND2	ENSCAFP00000015338	ENSCAFP00000011616	Iroquois homeobox 4.	Heart and neural crest derivatives expressed 2.	0.566
IRX4	IRX1	ENSCAFP00000015338	ENSCAFP00000015312	Iroquois homeobox 4.	Iroquois homeobox 1.	0.929
IRX4	KCNJ3	ENSCAFP00000015338	ENSCAFP00000013508	Iroquois homeobox 4.	Potassium voltage-gated channel subfamily J member 3.	0.731
IRX4	NPPA	ENSCAFP00000015338	ENSCAFP00000053231	Iroquois homeobox 4.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.732
IRX4	SCN5A	ENSCAFP00000015338	ENSCAFP00000007532	Iroquois homeobox 4.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.559