STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AGFG1ArfGAP with FG repeats 1. (506 aa)    
Predicted Functional Partners:
FAM126B
Family with sequence similarity 126 member B.
      
 0.889
EPS15
Epidermal growth factor receptor pathway substrate 15.
    
 
 0.845
EPS15L1
Epidermal growth factor receptor pathway substrate 15 like 1.
    
 
 0.748
CCDC62
Coiled-coil domain containing 62.
      
 0.610
CCDC88A
Coiled-coil domain containing 88A.
      
 0.592
BTBD18
BTB domain containing 18.
      
 0.589
MEAK7
MTOR associated protein, eak-7 homolog.
      
 0.578
GOLGA7B
Golgin A7 family member B.
      
 0.576
DDX49
DEAD-box helicase 49; Belongs to the DEAD box helicase family.
      
 0.555
RAB10
Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...]
      
 0.540
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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