PKNOX1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

PKNOX1

PBX/knotted 1 homeobox 1. (436 aa)

Predicted Functional Partners:

VWA5A

0.734

KIAA0355

0.724

PBX4

0.716

HOXB1

0.661

MYBBP1A

0.640

HMGB2

0.639

HMGB4

0.639

MED21

0.629

SHOX

0.618

MED30

0.598

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HMGB2	PKNOX1	ENSCAFP00000011606	ENSCAFP00000015472	High mobility group box 2.	PBX/knotted 1 homeobox 1.	0.639
HMGB4	PKNOX1	ENSCAFP00000038737	ENSCAFP00000015472	High mobility group box 4.	PBX/knotted 1 homeobox 1.	0.639
HOXB1	PBX4	ENSCAFP00000024764	ENSCAFP00000019597	Homeobox B1.	PBX homeobox 4.	0.653
HOXB1	PKNOX1	ENSCAFP00000024764	ENSCAFP00000015472	Homeobox B1.	PBX/knotted 1 homeobox 1.	0.661
KIAA0355	PKNOX1	ENSCAFP00000010894	ENSCAFP00000015472	KIAA0355.	PBX/knotted 1 homeobox 1.	0.724
MED21	MED30	ENSCAFP00000052409	ENSCAFP00000001180	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator complex subunit 30.	0.998
MED21	PKNOX1	ENSCAFP00000052409	ENSCAFP00000015472	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	PBX/knotted 1 homeobox 1.	0.629
MED30	MED21	ENSCAFP00000001180	ENSCAFP00000052409	Mediator complex subunit 30.	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.998
MED30	PKNOX1	ENSCAFP00000001180	ENSCAFP00000015472	Mediator complex subunit 30.	PBX/knotted 1 homeobox 1.	0.598
MYBBP1A	PBX4	ENSCAFP00000036879	ENSCAFP00000019597	MYB binding protein 1a.	PBX homeobox 4.	0.860
MYBBP1A	PKNOX1	ENSCAFP00000036879	ENSCAFP00000015472	MYB binding protein 1a.	PBX/knotted 1 homeobox 1.	0.640
PBX4	HOXB1	ENSCAFP00000019597	ENSCAFP00000024764	PBX homeobox 4.	Homeobox B1.	0.653
PBX4	MYBBP1A	ENSCAFP00000019597	ENSCAFP00000036879	PBX homeobox 4.	MYB binding protein 1a.	0.860
PBX4	PKNOX1	ENSCAFP00000019597	ENSCAFP00000015472	PBX homeobox 4.	PBX/knotted 1 homeobox 1.	0.716
PKNOX1	HMGB2	ENSCAFP00000015472	ENSCAFP00000011606	PBX/knotted 1 homeobox 1.	High mobility group box 2.	0.639
PKNOX1	HMGB4	ENSCAFP00000015472	ENSCAFP00000038737	PBX/knotted 1 homeobox 1.	High mobility group box 4.	0.639
PKNOX1	HOXB1	ENSCAFP00000015472	ENSCAFP00000024764	PBX/knotted 1 homeobox 1.	Homeobox B1.	0.661
PKNOX1	KIAA0355	ENSCAFP00000015472	ENSCAFP00000010894	PBX/knotted 1 homeobox 1.	KIAA0355.	0.724
PKNOX1	MED21	ENSCAFP00000015472	ENSCAFP00000052409	PBX/knotted 1 homeobox 1.	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.629
PKNOX1	MED30	ENSCAFP00000015472	ENSCAFP00000001180	PBX/knotted 1 homeobox 1.	Mediator complex subunit 30.	0.598