DAPP1 protein (Canis lupus familiaris) - STRING interaction network

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DAPP1

Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)

Predicted Functional Partners:

LYN

0.931

RAC2

0.884

DDIT4L

0.810

RAC1

0.786

RAC3

0.775

AP3B2

0.689

LCK

0.650

HCK

0.650

YES1

0.633

ARHGEF3

0.630

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP3B2	DAPP1	ENSCAFP00000019347	ENSCAFP00000015548	AP-3 complex subunit beta.	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	0.689
AP3B2	DDIT4L	ENSCAFP00000019347	ENSCAFP00000042338	AP-3 complex subunit beta.	DNA damage inducible transcript 4 like.	0.819
ARHGEF3	DAPP1	ENSCAFP00000011905	ENSCAFP00000015548	Rho guanine nucleotide exchange factor 3.	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	0.630
ARHGEF3	RAC1	ENSCAFP00000011905	ENSCAFP00000032062	Rho guanine nucleotide exchange factor 3.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.584
DAPP1	AP3B2	ENSCAFP00000015548	ENSCAFP00000019347	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	AP-3 complex subunit beta.	0.689
DAPP1	ARHGEF3	ENSCAFP00000015548	ENSCAFP00000011905	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	Rho guanine nucleotide exchange factor 3.	0.630
DAPP1	DDIT4L	ENSCAFP00000015548	ENSCAFP00000042338	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	DNA damage inducible transcript 4 like.	0.810
DAPP1	HCK	ENSCAFP00000015548	ENSCAFP00000032817	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	Tyrosine-protein kinase.	0.650
DAPP1	LCK	ENSCAFP00000015548	ENSCAFP00000015667	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	Tyrosine-protein kinase.	0.650
DAPP1	LYN	ENSCAFP00000015548	ENSCAFP00000046785	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	Tyrosine-protein kinase.	0.931
DAPP1	RAC1	ENSCAFP00000015548	ENSCAFP00000032062	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.786
DAPP1	RAC2	ENSCAFP00000015548	ENSCAFP00000002174	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	Rac family small GTPase 2.	0.884
DAPP1	RAC3	ENSCAFP00000015548	ENSCAFP00000008868	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	Uncharacterized protein.	0.775
DAPP1	YES1	ENSCAFP00000015548	ENSCAFP00000063973	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components su [...]	0.633
DDIT4L	AP3B2	ENSCAFP00000042338	ENSCAFP00000019347	DNA damage inducible transcript 4 like.	AP-3 complex subunit beta.	0.819
DDIT4L	DAPP1	ENSCAFP00000042338	ENSCAFP00000015548	DNA damage inducible transcript 4 like.	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	0.810
HCK	DAPP1	ENSCAFP00000032817	ENSCAFP00000015548	Tyrosine-protein kinase.	Dual adaptor of phosphotyrosine and 3-phosphoinositides 1.	0.650
HCK	LYN	ENSCAFP00000032817	ENSCAFP00000046785	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.957
HCK	RAC1	ENSCAFP00000032817	ENSCAFP00000032062	Tyrosine-protein kinase.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.414
HCK	RAC2	ENSCAFP00000032817	ENSCAFP00000002174	Tyrosine-protein kinase.	Rac family small GTPase 2.	0.435