Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
TMEM115Transmembrane protein 115. (351 aa)    
Predicted Functional Partners:
MUL1
Mitochondrial E3 ubiquitin protein ligase 1.
   
    0.804
UBL7
Ubiquitin like 7.
      
 0.691
TMEM184A
Transmembrane protein 184A.
      
 0.611
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6.
      
 0.609
COG7
Component of oligomeric golgi complex 7.
   
 
 0.566
STX5
Syntaxin 5; Belongs to the syntaxin family.
   
 
  0.565
COG2
Component of oligomeric golgi complex 2.
   
 
  0.557
PDF
Conserved oligomeric Golgi complex subunit 8; Belongs to the COG8 family.
   
 
 0.550
COPB1
Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
   
 
  0.545
TMEM135
Transmembrane protein 135.
      
 0.542
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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