STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH2Notch receptor 2. (2726 aa)    
Predicted Functional Partners:
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.993
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.988
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.986
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.986
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.
    
 0.970
NUMB
NUMB endocytic adaptor protein.
   
 0.965
MAML1
Mastermind like transcriptional coactivator 1.
   
 0.964
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.
   
 0.950
MAML3
Mastermind like transcriptional coactivator 3.
   
 0.949
JAG2
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
 
0.939
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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