LCK protein (Canis lupus familiaris) - STRING interaction network

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Score

LCK

Tyrosine-protein kinase. (509 aa)

Predicted Functional Partners:

ZAP70

0.983

PTPRC

0.980

CD4

0.969

CBL

0.962

LYN

0.957

CD8A

0.948

CD247

0.946

PIK3CB

0.944

ITK

0.940

PIK3R1

0.939

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	ITK	ENSCAFP00000046273	ENSCAFP00000025891	Cbl proto-oncogene.	Tyrosine-protein kinase.	0.539
CBL	LCK	ENSCAFP00000046273	ENSCAFP00000015667	Cbl proto-oncogene.	Tyrosine-protein kinase.	0.962
CBL	LYN	ENSCAFP00000046273	ENSCAFP00000046785	Cbl proto-oncogene.	Tyrosine-protein kinase.	0.970
CBL	PIK3CB	ENSCAFP00000046273	ENSCAFP00000011245	Cbl proto-oncogene.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.990
CBL	PIK3R1	ENSCAFP00000046273	ENSCAFP00000011322	Cbl proto-oncogene.	Phosphoinositide-3-kinase regulatory subunit 1.	0.995
CBL	ZAP70	ENSCAFP00000046273	ENSCAFP00000047083	Cbl proto-oncogene.	Tyrosine-protein kinase.	0.989
CD247	CD4	ENSCAFP00000041707	ENSCAFP00000063394	Uncharacterized protein.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.623
CD247	CD8A	ENSCAFP00000041707	ENSCAFP00000063962	Uncharacterized protein.	T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...]	0.940
CD247	ITK	ENSCAFP00000041707	ENSCAFP00000025891	Uncharacterized protein.	Tyrosine-protein kinase.	0.951
CD247	LCK	ENSCAFP00000041707	ENSCAFP00000015667	Uncharacterized protein.	Tyrosine-protein kinase.	0.946
CD247	LYN	ENSCAFP00000041707	ENSCAFP00000046785	Uncharacterized protein.	Tyrosine-protein kinase.	0.659
CD247	PIK3R1	ENSCAFP00000041707	ENSCAFP00000011322	Uncharacterized protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.842
CD247	PTPRC	ENSCAFP00000041707	ENSCAFP00000054600	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.720
CD247	ZAP70	ENSCAFP00000041707	ENSCAFP00000047083	Uncharacterized protein.	Tyrosine-protein kinase.	0.999
CD4	CD247	ENSCAFP00000063394	ENSCAFP00000041707	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Uncharacterized protein.	0.623
CD4	CD8A	ENSCAFP00000063394	ENSCAFP00000063962	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...]	0.988
CD4	ITK	ENSCAFP00000063394	ENSCAFP00000025891	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Tyrosine-protein kinase.	0.620
CD4	LCK	ENSCAFP00000063394	ENSCAFP00000015667	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Tyrosine-protein kinase.	0.969
CD4	LYN	ENSCAFP00000063394	ENSCAFP00000046785	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Tyrosine-protein kinase.	0.817
CD4	PIK3CB	ENSCAFP00000063394	ENSCAFP00000011245	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.528