STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HYAL2Hyaluronidase. (472 aa)    
Predicted Functional Partners:
ASL
Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.
   
 
 0.937
ARSB
Arylsulfatase B.
   
 
 0.932
CD44
CD44 antigen.
    
 0.870
HAS2
Hyaluronan synthase 2.
   
  
 0.708
LYVE1
Lymphatic vessel endothelial hyaluronan receptor 1.
   
 0.682
HMMR
Hyaluronan mediated motility receptor.
   
 0.664
ACAN
Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
   
 
 0.647
STAB2
Stabilin 2.
     
 0.625
HAS1
Hyaluronan synthase 1.
   
  
 0.604
ITSN2
Intersectin 2.
   
 
 0.604
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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