HYAL3 protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

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Score

HYAL3

Hyaluronidase. (418 aa)

Predicted Functional Partners:

ASL

0.937

ARSB

0.923

CD44

0.746

ACAN

0.705

HAS2

0.671

INS

0.630

HAS3

0.623

HAS1

0.615

ITSN2

0.603

CD4

0.599

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	CD44	ENSCAFP00000065577	ENSCAFP00000050335	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	CD44 antigen.	0.669
ACAN	HAS1	ENSCAFP00000065577	ENSCAFP00000004163	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Hyaluronan synthase 1.	0.474
ACAN	HAS2	ENSCAFP00000065577	ENSCAFP00000042994	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Hyaluronan synthase 2.	0.579
ACAN	HAS3	ENSCAFP00000065577	ENSCAFP00000030096	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Hyaluronan synthase 3.	0.607
ACAN	HYAL3	ENSCAFP00000065577	ENSCAFP00000015697	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Hyaluronidase.	0.705
ACAN	INS	ENSCAFP00000065577	ENSCAFP00000051648	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.544
ARSB	ASL	ENSCAFP00000013492	ENSCAFP00000014967	Arylsulfatase B.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.715
ARSB	HYAL3	ENSCAFP00000013492	ENSCAFP00000015697	Arylsulfatase B.	Hyaluronidase.	0.923
ASL	ARSB	ENSCAFP00000014967	ENSCAFP00000013492	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	Arylsulfatase B.	0.715
ASL	HYAL3	ENSCAFP00000014967	ENSCAFP00000015697	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	Hyaluronidase.	0.937
CD4	CD44	ENSCAFP00000063394	ENSCAFP00000050335	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	CD44 antigen.	0.865
CD4	HYAL3	ENSCAFP00000063394	ENSCAFP00000015697	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Hyaluronidase.	0.599
CD4	INS	ENSCAFP00000063394	ENSCAFP00000051648	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.656
CD44	ACAN	ENSCAFP00000050335	ENSCAFP00000065577	CD44 antigen.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.669
CD44	CD4	ENSCAFP00000050335	ENSCAFP00000063394	CD44 antigen.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.865
CD44	HAS1	ENSCAFP00000050335	ENSCAFP00000004163	CD44 antigen.	Hyaluronan synthase 1.	0.538
CD44	HAS2	ENSCAFP00000050335	ENSCAFP00000042994	CD44 antigen.	Hyaluronan synthase 2.	0.769
CD44	HAS3	ENSCAFP00000050335	ENSCAFP00000030096	CD44 antigen.	Hyaluronan synthase 3.	0.628
CD44	HYAL3	ENSCAFP00000050335	ENSCAFP00000015697	CD44 antigen.	Hyaluronidase.	0.746
CD44	INS	ENSCAFP00000050335	ENSCAFP00000051648	CD44 antigen.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.659