NLRP3 protein (Canis lupus familiaris) - STRING interaction network

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Score

NLRP3

NLR family pyrin domain containing 3. (1065 aa)

Predicted Functional Partners:

IL1B

0.968

PYCARD

0.965

NEK7

0.950

CTSB

0.923

TXNIP

0.917

RELA

0.914

SUGT1

0.911

CARD8

0.908

NFKB1

0.908

HSP90AB1

0.907

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD8	NLRP3	ENSCAFP00000053507	ENSCAFP00000015730	Uncharacterized protein.	NLR family pyrin domain containing 3.	0.908
CTSB	IL1B	ENSCAFP00000059573	ENSCAFP00000010762	Cathepsin B; Belongs to the peptidase C1 family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.604
CTSB	NLRP3	ENSCAFP00000059573	ENSCAFP00000015730	Cathepsin B; Belongs to the peptidase C1 family.	NLR family pyrin domain containing 3.	0.923
HSP90AB1	NLRP3	ENSCAFP00000002914	ENSCAFP00000015730	Heat shock protein 90 alpha family class B member 1.	NLR family pyrin domain containing 3.	0.907
HSP90AB1	SUGT1	ENSCAFP00000002914	ENSCAFP00000007201	Heat shock protein 90 alpha family class B member 1.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.961
IL1B	CTSB	ENSCAFP00000010762	ENSCAFP00000059573	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Cathepsin B; Belongs to the peptidase C1 family.	0.604
IL1B	NEK7	ENSCAFP00000010762	ENSCAFP00000059247	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	NIMA related kinase 7; Belongs to the protein kinase superfamily.	0.462
IL1B	NFKB1	ENSCAFP00000010762	ENSCAFP00000056706	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]	0.957
IL1B	NLRP3	ENSCAFP00000010762	ENSCAFP00000015730	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	NLR family pyrin domain containing 3.	0.968
IL1B	PYCARD	ENSCAFP00000010762	ENSCAFP00000024803	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	PYD and CARD domain containing.	0.975
IL1B	RELA	ENSCAFP00000010762	ENSCAFP00000019655	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	RELA proto-oncogene, NF-kB subunit.	0.961
IL1B	TXNIP	ENSCAFP00000010762	ENSCAFP00000016786	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Thioredoxin interacting protein.	0.610
NEK7	IL1B	ENSCAFP00000059247	ENSCAFP00000010762	NIMA related kinase 7; Belongs to the protein kinase superfamily.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.462
NEK7	NLRP3	ENSCAFP00000059247	ENSCAFP00000015730	NIMA related kinase 7; Belongs to the protein kinase superfamily.	NLR family pyrin domain containing 3.	0.950
NEK7	PYCARD	ENSCAFP00000059247	ENSCAFP00000024803	NIMA related kinase 7; Belongs to the protein kinase superfamily.	PYD and CARD domain containing.	0.689
NFKB1	IL1B	ENSCAFP00000056706	ENSCAFP00000010762	Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.957
NFKB1	NLRP3	ENSCAFP00000056706	ENSCAFP00000015730	Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]	NLR family pyrin domain containing 3.	0.908
NFKB1	RELA	ENSCAFP00000056706	ENSCAFP00000019655	Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]	RELA proto-oncogene, NF-kB subunit.	0.998
NLRP3	CARD8	ENSCAFP00000015730	ENSCAFP00000053507	NLR family pyrin domain containing 3.	Uncharacterized protein.	0.908
NLRP3	CTSB	ENSCAFP00000015730	ENSCAFP00000059573	NLR family pyrin domain containing 3.	Cathepsin B; Belongs to the peptidase C1 family.	0.923