NLRP3 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

NLRP3

NLR family pyrin domain containing 3. (1065 aa)

Predicted Functional Partners:

PYCARD

0.991

CASP4

0.989

GSDMD

0.967

CARD8

0.961

CASP12

0.951

NLRP1

0.910

SUGT1

0.903

IL1B

0.897

NEK7

0.836

BRCC3

0.820

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCC3	NLRP3	ENSCAFP00000039536	ENSCAFP00000015730	BRCA1/BRCA2-containing complex subunit 3.	NLR family pyrin domain containing 3.	0.820
CARD8	CASP12	ENSCAFP00000053507	ENSCAFP00000042646	Uncharacterized protein.	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	0.907
CARD8	CASP4	ENSCAFP00000053507	ENSCAFP00000031566	Uncharacterized protein.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.941
CARD8	GSDMD	ENSCAFP00000053507	ENSCAFP00000033873	Uncharacterized protein.	Gasdermin D.	0.952
CARD8	IL1B	ENSCAFP00000053507	ENSCAFP00000010762	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.541
CARD8	NLRP1	ENSCAFP00000053507	ENSCAFP00000022816	Uncharacterized protein.	NLR family pyrin domain containing 1.	0.969
CARD8	NLRP3	ENSCAFP00000053507	ENSCAFP00000015730	Uncharacterized protein.	NLR family pyrin domain containing 3.	0.961
CARD8	PYCARD	ENSCAFP00000053507	ENSCAFP00000024803	Uncharacterized protein.	PYD and CARD domain containing.	0.940
CASP12	CARD8	ENSCAFP00000042646	ENSCAFP00000053507	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	Uncharacterized protein.	0.907
CASP12	CASP4	ENSCAFP00000042646	ENSCAFP00000031566	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.991
CASP12	GSDMD	ENSCAFP00000042646	ENSCAFP00000033873	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	Gasdermin D.	0.991
CASP12	IL1B	ENSCAFP00000042646	ENSCAFP00000010762	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.960
CASP12	NLRP1	ENSCAFP00000042646	ENSCAFP00000022816	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	NLR family pyrin domain containing 1.	0.962
CASP12	NLRP3	ENSCAFP00000042646	ENSCAFP00000015730	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	NLR family pyrin domain containing 3.	0.951
CASP12	PYCARD	ENSCAFP00000042646	ENSCAFP00000024803	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	PYD and CARD domain containing.	0.996
CASP4	CARD8	ENSCAFP00000031566	ENSCAFP00000053507	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Uncharacterized protein.	0.941
CASP4	CASP12	ENSCAFP00000031566	ENSCAFP00000042646	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	0.991
CASP4	GSDMD	ENSCAFP00000031566	ENSCAFP00000033873	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Gasdermin D.	0.998
CASP4	IL1B	ENSCAFP00000031566	ENSCAFP00000010762	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.996
CASP4	NEK7	ENSCAFP00000031566	ENSCAFP00000059247	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NIMA related kinase 7; Belongs to the protein kinase superfamily.	0.682