DNMT3L protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DNMT3L

Uncharacterized protein. (155 aa)

Predicted Functional Partners:

DNMT3A

0.986

DNMT3B

0.871

DNMT1

0.781

TET1

0.709

TET3

0.687

TRDMT1

0.679

TET2

0.674

F1P7D7_CANLF

0.632

ATRX

0.610

UHRF1

0.608

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRX	DNMT1	ENSCAFP00000025411	ENSCAFP00000026412	ATRX chromatin remodeler.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.546
ATRX	DNMT3A	ENSCAFP00000025411	ENSCAFP00000006185	ATRX chromatin remodeler.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.441
ATRX	DNMT3L	ENSCAFP00000025411	ENSCAFP00000015781	ATRX chromatin remodeler.	Uncharacterized protein.	0.610
DNMT1	ATRX	ENSCAFP00000026412	ENSCAFP00000025411	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	ATRX chromatin remodeler.	0.546
DNMT1	DNMT3A	ENSCAFP00000026412	ENSCAFP00000006185	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.966
DNMT1	DNMT3B	ENSCAFP00000026412	ENSCAFP00000010821	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.962
DNMT1	DNMT3L	ENSCAFP00000026412	ENSCAFP00000015781	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.781
DNMT1	F1P7D7_CANLF	ENSCAFP00000026412	ENSCAFP00000017855	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.501
DNMT1	TET1	ENSCAFP00000026412	ENSCAFP00000038827	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 1.	0.755
DNMT1	TET2	ENSCAFP00000026412	ENSCAFP00000015986	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 2.	0.762
DNMT1	TET3	ENSCAFP00000026412	ENSCAFP00000012834	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 3.	0.769
DNMT1	TRDMT1	ENSCAFP00000026412	ENSCAFP00000006788	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.458
DNMT1	UHRF1	ENSCAFP00000026412	ENSCAFP00000027947	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Ubiquitin like with PHD and ring finger domains 1.	0.992
DNMT3A	ATRX	ENSCAFP00000006185	ENSCAFP00000025411	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	ATRX chromatin remodeler.	0.441
DNMT3A	DNMT1	ENSCAFP00000006185	ENSCAFP00000026412	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.966
DNMT3A	DNMT3B	ENSCAFP00000006185	ENSCAFP00000010821	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.515
DNMT3A	DNMT3L	ENSCAFP00000006185	ENSCAFP00000015781	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.986
DNMT3A	F1P7D7_CANLF	ENSCAFP00000006185	ENSCAFP00000017855	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.491
DNMT3A	TET1	ENSCAFP00000006185	ENSCAFP00000038827	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 1.	0.752
DNMT3A	TET2	ENSCAFP00000006185	ENSCAFP00000015986	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 2.	0.819

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.788

expected number of edges:

11

PPI enrichment p-value:

2.85e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042558

Pteridine-containing compound metabolic process

3 of 10

1.68

1.2

0.0031

GO:0006431

methionyl-tRNA aminoacylation

2 of 2

2.21

1.09

0.0092

GO:0006520

Cellular amino acid metabolic process

6 of 86

1.05

0.94

0.00052

GO:0009086

Methionine biosynthetic process

2 of 5

1.81

0.89

0.0185

GO:0016070

RNA metabolic process

6 of 98

0.99

0.84

0.00098

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004825

methionine-tRNA ligase activity

2 of 2

2.21

0.82

0.0309

GO:0016741

Transferase activity, transferring one-carbon groups

4 of 34

1.28

0.71

0.0235

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 4

1.91

0.7

0.0473

GO:0016646

Oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

2 of 6

1.73

0.68

0.0474

GO:0140101

Catalytic activity, acting on a tRNA

4 of 43

1.17

0.65

0.0276

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

7 of 178

0.8

0.63

0.0021

GO:0005622

Intracellular anatomical structure

11 of 747

0.37

0.31

0.0031

GO:0005737

Cytoplasm

10 of 672

0.38

0.3

0.0120

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:362

16S rRNA methyltransferase RsmB/F, and Formyl transferase

4 of 5

2.11

2.22

3.83e-05

CL:291

tRNA aminoacylation

3 of 13

1.57

1.03

0.0061

CL:79

Translation, and RNA biosynthetic process

7 of 147

0.88

0.71

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cgo00670

One carbon pool by folate

5 of 9

1.95

2.85

5.07e-07

cgo00450

Selenocompound metabolism

3 of 6

1.91

1.59

0.00060

cgo00970

Aminoacyl-tRNA biosynthesis

4 of 27

1.38

1.24

0.00063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0648

Protein biosynthesis

5 of 41

1.29

1.17

0.00060

KW-0030

Aminoacyl-tRNA synthetase

3 of 23

1.32

0.67

0.0333

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