AIRE protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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[Homology]

Score

AIRE

Autoimmune regulator. (583 aa)

Predicted Functional Partners:

FOXN1

0.857

FOXP3

0.791

GMEB1

0.739

CREBBP

0.722

CD80

0.686

CD40

0.602

HDAC3

0.592

HDAC1

0.592

HDAC8

0.592

HDAC2

0.592

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIRE	CD40	ENSCAFP00000015791	ENSCAFP00000061346	Autoimmune regulator.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.602
AIRE	CD80	ENSCAFP00000015791	ENSCAFP00000016197	Autoimmune regulator.	CD80 molecule.	0.686
AIRE	CREBBP	ENSCAFP00000015791	ENSCAFP00000036447	Autoimmune regulator.	CREB binding protein.	0.722
AIRE	FOXN1	ENSCAFP00000015791	ENSCAFP00000027604	Autoimmune regulator.	Forkhead box N1.	0.857
AIRE	FOXP3	ENSCAFP00000015791	ENSCAFP00000023435	Autoimmune regulator.	Forkhead box P3.	0.791
AIRE	GMEB1	ENSCAFP00000015791	ENSCAFP00000017230	Autoimmune regulator.	Glucocorticoid modulatory element binding protein 1.	0.739
AIRE	HDAC1	ENSCAFP00000015791	ENSCAFP00000036819	Autoimmune regulator.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.592
AIRE	HDAC2	ENSCAFP00000015791	ENSCAFP00000042408	Autoimmune regulator.	Histone deacetylase 2.	0.592
AIRE	HDAC3	ENSCAFP00000015791	ENSCAFP00000030390	Autoimmune regulator.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.592
AIRE	HDAC8	ENSCAFP00000015791	ENSCAFP00000040790	Autoimmune regulator.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.592
CD40	AIRE	ENSCAFP00000061346	ENSCAFP00000015791	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	Autoimmune regulator.	0.602
CD40	CD80	ENSCAFP00000061346	ENSCAFP00000016197	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	CD80 molecule.	0.955
CD40	FOXP3	ENSCAFP00000061346	ENSCAFP00000023435	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	Forkhead box P3.	0.711
CD80	AIRE	ENSCAFP00000016197	ENSCAFP00000015791	CD80 molecule.	Autoimmune regulator.	0.686
CD80	CD40	ENSCAFP00000016197	ENSCAFP00000061346	CD80 molecule.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.955
CD80	FOXP3	ENSCAFP00000016197	ENSCAFP00000023435	CD80 molecule.	Forkhead box P3.	0.878
CREBBP	AIRE	ENSCAFP00000036447	ENSCAFP00000015791	CREB binding protein.	Autoimmune regulator.	0.722
CREBBP	FOXP3	ENSCAFP00000036447	ENSCAFP00000023435	CREB binding protein.	Forkhead box P3.	0.429
CREBBP	HDAC1	ENSCAFP00000036447	ENSCAFP00000036819	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.804
CREBBP	HDAC2	ENSCAFP00000036447	ENSCAFP00000042408	CREB binding protein.	Histone deacetylase 2.	0.589